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Fentanyl

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Identification
Molecular formula
C22H28N2O
CAS number
437-38-7
IUPAC name
2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanone
State
State

At room temperature, fentanyl is typically in a solid state as a crystalline powder. It is stable under normal conditions of use and storage.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
401.00
Boiling point (Kelvin)
674.15
General information
Molecular weight
336.47g/mol
Molar mass
336.4710g/mol
Density
1.3350g/cm3
Appearence

Fentanyl is a white, odorless, crystalline powder. In some forms, it can appear as a solution or pill, but the pure compound is primarily a crystalline solid.

Comment on solubility

Solubility of 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanone

The solubility of chemical compounds is crucial for various applications, particularly in pharmaceuticals, where effective dissolution influences bioavailability. For the compound 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanone (C22H28N2O), several factors come into play:

  • Polarity: Given the presence of functional groups like the hydroxyl group, this compound exhibits polar characteristics, which can enhance its solubility in polar solvents such as water and various organic solvents.
  • Hydrophobic Interactions: The phenyl groups contribute a hydrophobic character, which may limit solubility in strictly polar environments, thus indicating that it might be more soluble in hydrophobic solvents.
  • Temperature Dependence: As with many organic molecules, solubility can increase with temperature, making it essential to consider the temperature during dissolution assessments.
  • pH Sensitivity: The presence of a hydroxyl group suggests potential ionization under varying pH conditions, which could further influence solubility dynamics.

Overall, the solubility of this compound can be characterized as moderate, with varying solubility profiles in different solvents, depending on environmental conditions and formulation aspects. Understanding these parameters is essential for optimizing its utilization in practical applications.

Interesting facts

Exploring 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanone

2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanone is a fascinating compound that is noteworthy for its diverse applications in the field of medicinal chemistry. Here are some intriguing aspects about this molecule:

  • Structural Complexity: The compound features a complex structure that includes a piperidine ring. This structural diversity often translates into unique biological activities.
  • Pharmacological Potential: Molecules with piperidine moieties are frequently explored for their potential in developing therapeutic agents. Its ability to interact with various receptors may be of interest in drug design.
  • Curious Functionality: The presence of a phenyl group and a hydroxy group suggests potential for intriguing interactions in biological systems, especially in ligand-receptor binding.
  • Historical Significance: Compounds featuring similar frameworks have been used in creating drugs for various conditions, including analgesics and psychoactive substances, illustrating the vast potential embedded in its structure.

As a researcher or student in the field of chemistry, investigating such compounds can lead to new discoveries. Understanding the relationship between structure and activity remains a key focus, igniting curiosity about how small changes in molecular structure can produce significant shifts in biological efficacy. The continuous study of compounds like this one fuels advancements in pharmacology and organic synthesis.


In conclusion, 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanone serves as a profound reminder of the complexity and potential of organic molecules in shaping the future of medicine.

Synonyms
lobeline
Lobelin
CHEMBL15476
90-69-7
alpha-Lobeline;L-Lobeline
2-(6-(2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one
10122-32-4
SMR000151480
Lobeline,Alpha
2-[6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl]-1-phenylethan-1-one
Lobeline, (-)
L-LOBELINE
Spectrum_000920
Spectrum2_001361
Spectrum3_000033
Spectrum4_000818
Spectrum4_001144
Spectrum5_001494
Oprea1_328362
BSPBio_001725
KBioGR_001335
KBioGR_001687
KBioSS_001400
MLS000536557
MLS006011485
DivK1c_000437
SCHEMBL290804
SPBio_001282
2-(6-(.beta.-Hydroxy-phenethyl)-1-methyl-2-piperidyl)acetophenone
2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone
KBio1_000437
KBio2_001400
KBio2_003968
KBio2_006536
KBio3_000865
DTXSID60859157
NINDS_000437
HMS2269F10
Ethanone, 2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, [2R-[2.alpha.,6.alpha.(S*)]]-
BDBM50047021
PDSP1_000121
PDSP2_000121
AKOS001063543
SDCCGMLS-0066606.P001
IDI1_000437
NCGC00015606-03
NCGC00015606-06
OL174235
SBI-0051600.P002
AB00053582-08
AB00053582_10
BRD-A65243462-001-07-1
BRD-A65243462-003-03-6
BRD-A65243462-003-04-4
Z56933708
2-[6-(2-Hydroxy-2-phenyl-ethyl)-1-methyl-piperidin-2-yl]-1-phenyl-ethanone
2-[6-(2-Hydroxy-2-phenyl-ethyl)-1-methyl-piperidin-2-yl]-1-phenyl-ethanone (lobeline)