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Loratadine

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Identification
Molecular formula
C22H23ClN2O
CAS number
79794-75-5
IUPAC name
2-[(6-chloro-1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]-N,N-dimethyl-ethanamine
State
State

At room temperature, Loratadine is in a solid state, typically as a crystalline powder.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
478.60
Boiling point (Kelvin)
751.80
General information
Molecular weight
382.88g/mol
Molar mass
382.8780g/mol
Density
1.3000g/cm3
Appearence

Loratadine is typically a white to off-white crystalline powder. It is important for compounds to be in this pure form to ensure potency and effectiveness in pharmaceuticals, such as in antihistamines, where Loratadine is commonly used.

Comment on solubility

Solubility of 2-[(6-chloro-1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]-N,N-dimethyl-ethanamine

The solubility of this compound is quite intriguing due to its complex structure which influences its interactions with solvents. Several factors play a crucial role in determining its solubility:

  • Molecular Structure: The presence of both hydrophobic tetracyclic structures and polar amine groups can create variable solubility behavior.
  • Solvent Type: This compound may exhibit different solubility in various solvents such as:
    • Polar solvents like water may not dissolve it well due to its large hydrophobic components.
    • Non-polar solvents may facilitate better solubility, highlighting the significance of solvent interactions.
  • Temperature Effects: Higher temperatures generally increase solubility for many organic compounds as kinetic energy helps overcome intermolecular attractions.

In conclusion, the solubility of 2-[(6-chloro-1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]-N,N-dimethyl-ethanamine is expected to vary significantly based on its environment. Understanding these solubility characteristics is vital for applications and synthesis in the field of chemistry.


Interesting facts

Interesting Facts about 2-[(6-chloro-1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]-N,N-dimethyl-ethanamine

This compound has garnered interest in the field of organic and medicinal chemistry due to its unique structure and potential applications. Here are some intriguing aspects of this compound:

  • Complex Structure: The molecule exhibits a multi-ring system, specifically a tetracyclo structure, which contributes to its stability and unique reactivity. Complex structures like these are often key in the development of novel materials and pharmaceuticals.
  • Chlorine Substitution: The presence of a chlorine atom in the structure may enhance the compound's biological activity. Chlorinated compounds are frequently found in many pharmaceuticals because they can improve the compound's ability to interact with biological targets.
  • Dimethylaminopropyl Chain: The N,N-dimethyl group increases the compound's lipophilicity, which can aid in the absorption and penetration of biological membranes, making it interesting for applications in drug delivery.
  • Potential Pharmaceutical Applications: Compounds with such complex frameworks are often investigated for their potential therapeutic effects, including anti-cancer and anti-inflammatory properties.
  • Research Interest: Scientists are particularly focused on such compounds because they can offer insights into the development of new classes of drugs that target specific pathways in diseases.

Overall, 2-[(6-chloro-1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]-N,N-dimethyl-ethanamine presents a fascinating case study in the intersection of organic chemistry, pharmacology, and medicinal research. Continued exploration of this compound could lead to groundbreaking discoveries in drug development.