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Etodolac

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Identification
Molecular formula
C17H15ClNO4
CAS number
41340-25-4
IUPAC name
2-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]acetic acid
State
State

At room temperature, Etodolac is typically a solid substance. It is often utilized in pharmaceutical formulations as a crystalline powder.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
570.00
Boiling point (Kelvin)
843.15
General information
Molecular weight
287.71g/mol
Molar mass
287.7110g/mol
Density
1.3875g/cm3
Appearence

Etodolac is generally found in crystalline forms. It is often seen as a white to off-white powder. The solid's appearance can differ slightly based on particle size and purity.

Comment on solubility

Solubility of 2-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]acetic acid

The solubility of 2-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]acetic acid can be influenced by several factors, including its chemical structure and the nature of the solvent. This compound, characterized by its unique chromene structure, generally displays the following solubility properties:

  • Polar Solvents: Due to the presence of the carboxylic acid functional group, this compound is likely to be soluble in polar solvents like water and methanol.
  • Non-Polar Solvents: It may have limited solubility in non-polar solvents, such as hexane or chloroform, owing to its polar functional groups which favor interactions with polar entities.
  • pH Dependence: The solubility can also be affected by the pH of the solution. In acidic conditions, the carboxylic acid group may remain in its protonated form, which can affect its overall solubility profile.

To quote a prevalent principle in chemistry, "like dissolves like." This means that polar compounds tend to dissolve well in polar solvents, whereas non-polar compounds favor non-polar solvents. Thus, the structural characteristics of 2-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]acetic acid suggest its solubility will be greatest in polar environments.

In conclusion, while further empirical studies could provide more precise solubility data, the presence of polar functional groups indicates that this compound is likely to be soluble in polar solvents under suitable conditions.

Interesting facts

Interesting Facts about 2-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]acetic acid

This intriguing compound belongs to a class of organic molecules that are often studied for their biological activities and role in medicinal chemistry. It features a unique chromene structure, which is significant due to its applications in various fields such as pharmaceuticals and materials science.

Key Highlights:

  • Biological Relevance: Chromene derivatives have been extensively investigated for their potential therapeutic effects. Compounds like this one have shown promise in anti-inflammatory, antioxidant, and anticancer activities.
  • Structural Complexity: The presence of functional groups like the amino and carbonyl moieties highlights the compound's potential to engage in various chemical reactions, particularly in the realm of drug design.
  • Synthetic Pathways: The synthesis of this compound may involve multiple steps, including condensation and cyclization reactions. This can be an excellent exercise for students in organic chemistry to explore reaction mechanisms and strategies.
  • Research Opportunities: Due to its unique structure and properties, there is an ongoing interest in modifying this compound to enhance its efficacy or reduce potential side effects. This opens avenues for research in medicinal chemistry.
  • Natural Analogues: Some chromene compounds are found in nature, serving as important secondary metabolites in various plants. This demonstrates the connection between natural product chemistry and synthetic development.

As a chemistry student or scientist, studying compounds like 2-[(6-chloro-4-oxo-chromene-2-carbonyl)amino]acetic acid not only deepens our understanding of organic synthesis but also highlights the interplay between structure, function, and biological activity. It reminds us that chemistry is not just about reactions; it's about innovation and discovery!

Synonyms
27455-39-6
GLYCINE, N-((6-CHLORO-4-OXO-4H-1-BENZOPYRAN-2-YL)CARBONYL)-
BRN 1393084
N-((6-Chloro-4-oxo-4H-1-benzopyran-2-yl)carbonyl)glycine
DTXSID10181874