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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
2-(6-methoxy-2-naphthyl)propanoic acid
State
State

Naproxen is a solid at room temperature, typically found in a crystalline or powdered form due to its pharmaceutical use.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
215.40
Boiling point (Kelvin)
488.55
General information
Molecular weight
230.26g/mol
Molar mass
230.2610g/mol
Density
1.1540g/cm3
Appearence

Naproxen appears as a crystalline solid that is white to off-white in color. It is commonly used in medicine, so the solid might be found in a powdered form in pharmaceutical uses.

Comment on solubility

Solubility of 2-(6-methoxy-2-naphthyl)propanoic acid (C14H14O3)

The solubility of 2-(6-methoxy-2-naphthyl)propanoic acid, an organic compound with interesting pharmacological properties, can be characterized as follows:

  • Solvent Compatibility: This compound tends to exhibit varying solubility in different solvents. It is generally more soluble in organic solvents such as ethanol and acetone, while showing limited solubility in water.
  • Hydrophobic Characteristics: The presence of the naphthyl moiety contributes to its hydrophobic nature, which often results in reduced solubility in polar solvents.
  • Temperature Effects: Like many organic acids, solubility can increase with temperature, making it more feasible to dissolve in organic solvents when heated.
  • pH Influence: The solubility may also vary with pH, as the carboxylic acid group can lose a proton under basic conditions, potentially enhancing solubility in aqueous solutions due to increased ionization.

In summary, while 2-(6-methoxy-2-naphthyl)propanoic acid is soluble in certain organic solvents, its overall solubility profile reflects its complex structure. Knowing how environmental factors influence solubility can lead to better understanding of its behavior in various applications.

Interesting facts

Interesting Facts about 2-(6-methoxy-2-naphthyl)propanoic acid

2-(6-methoxy-2-naphthyl)propanoic acid is a fascinating compound that holds significance in various fields, especially in medicinal chemistry. Here are some compelling aspects of this compound:

  • Pharmaceutical Relevance: This compound is often investigated for its potential anti-inflammatory and analgesic properties. Its unique structure allows it to interact with biological systems in specific ways, making it a subject of interest in drug development.
  • Structural Characteristics: The compound features a naphthalene moiety, which is known for its aromatic stability. The presence of the methoxy group enhances its lipophilicity, allowing for better absorption in biological systems.
  • Carbon Chain Length: The propanoic acid functional group contributes to its acid characteristics, which can be significant in chemical reactions involving esterifications or salt formations.
  • Research Scope: Scientists are continually studying derivatives of this compound to optimize its efficacy and reduce potential side effects, which is crucial in the development of safer pharmaceuticals.
  • Environment and Synthesis: The synthesis of 2-(6-methoxy-2-naphthyl)propanoic acid often involves complex organic reactions, highlighting the importance of sustainable practices in chemistry to minimize waste and enhance yields.

This compound, therefore, stands out not only for its potential applications in medicine but also for its rich chemical structure, demonstrating the intricate connections between chemistry and biology. The exploration of such compounds is vital in paving the way for the next generation of therapeutics.

Synonyms
23981-80-8
2-(6-methoxynaphthalen-2-yl)propanoic acid
DL-Naproxen
2-(6-Methoxy-2-naphthyl)propionic acid
(+/-)-2-(6-Methoxy-2-naphthyl)propionic Acid
Racemic Naproxen
rac-naproxen
26159-31-9
2-(6-Methoxy-2-naphthyl)propanoic acid
(RS)-Naproxen
(+/-)-naproxen
MFCD00439456
Naproxen (racemic)
(+/-)-Naproxen-d3
( inverted exclamation markA)-Naproxen
(+/-)-6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid
2-(6-Methoxy-naphthalen-2-yl)-propionic acid
SMR001233475
rac Naproxen
EINECS 245-969-2
6-methoxy-alpha-methyl-2-naphthaleneacetic acid
alpha-(6-Methoxy-2-naphthyl)propionic acid
Prestwick3_000045
Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid
(+-)-2-(6-methoxy-2-naphthyl)propionic acid
2-(6-Methoxy-naphthalen-2-yl)-propionic acid(Naproxen)
EC 247-485-7
Oprea1_018821
BSPBio_000169
MLS002154184
MLS006011863
CHEMBL12952
SCHEMBL145769
BPBio1_000187
SCHEMBL10029028
CHEBI:91939
DTXSID70860274
HMS2095I11
HMS2230K21
HMS3374N03
HMS3712I11
ALBB-027257
INB29379
BBL038237
BDBM50009860
STK301546
AKOS000121315
AKOS016038194
CCG-220045
CS-W009085
FN27551
2-(6-methoxy-2-naphtyl)propionic acid
NCGC00021127-02
NCGC00021127-03
NCGC00021127-04
NCGC00021127-05
NCGC00094733-01
NCGC00094733-02
NCGC00094733-03
2-(6-methoxy-2-naphthyl)-propionic acid
2-(6-methoxynaphth-2-yl)-propionic acid
AC-25684
AS-47598
HY-15029
SY015060
SY051309
2-(6-methoxynaphthalen-2-yl)propanoicacid
2-(6-methoxy-2-naphthalenyl)propanoic acid
6-methoxy-2naphthyl-alpha-methylacetic acid
DB-007955
DB-045844
DB-046309
DB-046847
()-2-(6-methoxy-2-naphthyl)propionic acid
6-methoxy-2-naphthyl-alpha-methylacetic acid
6-methoxy-alpha-methyl-2-naphthylacetic acid
AB00513799
M1220
NS00000213
(+)2-(6-methoxy-2-naphthyl) propionic acid
EN300-21613
6-methoxy-alpha-methyl-2-naphthalenacetic acid
F14583
(+)-alpha-(6-methoxy-2-naphthyl)propionic acid
racemic 2-(6-methoxy-2-naphthyl)propionic acid
(+)-alpha-methyl-6-methoxy-2-naphthylacetic acid
(+/-)-2-(6-methoxy-2-naphthyl) propionic acid
(RS)-2-(6-methoxynaphthalen-2-yl)propanoic acid
2-naphthaleneacetic acid, 6-methoxy-alpha-methyl-
2-(6-Methoxy-2-naphthyl)propanoic acid, AldrichCPR
BRD-A87719232-001-02-4
Q27163737
Z104505002
( inverted exclamation markA)-2-(6-Methoxy-2-naphthyl)propionic Acid
(RS)-naproxen;(+/-)-2-(6-Methoxy-2-naphthalenyl)propionic acid;(+/-)-2-(6-Methoxy-2-naphthyl)propionic acid;DL-Naproxen
245-969-2