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Aptazapine

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Identification
Molecular formula
C18H22N2
CAS number
58665-75-9
IUPAC name
2-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine
State
State

At room temperature, aptazapine is in a solid state.

Melting point (Celsius)
93.50
Melting point (Kelvin)
366.65
Boiling point (Celsius)
277.00
Boiling point (Kelvin)
550.15
General information
Molecular weight
286.39g/mol
Molar mass
286.3900g/mol
Density
1.1764g/cm3
Appearence

Aptazapine typically appears as a white to off-white powder. It is crystalline in nature and is usually provided in solid form.

Comment on solubility

Solubility of 2-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine

The solubility of 2-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine can be quite intriguing due to its complex structure. Understanding its solubility behavior is essential for applications in pharmaceuticals and material sciences.

Factors Influencing Solubility

The solubility of this compound may be affected by several key factors:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents.
  • Hydrogen Bonding: Ability to form hydrogen bonds can significantly aid in dissolving the compound in appropriate solvents.
  • Temperature: Increased temperature generally improves solubility, promoting the dissolution process.
  • pH: The ionization of the compound at different pH levels can impact its solubility in aqueous environments.

Solvent Compatibility

This compound may show varying solubility in different types of solvents:

  • Water: Limited solubility due to its hydrophobic characteristics.
  • Organic Solvents: More soluble in organic solvents such as ethanol, methanol, or DMSO due to its nonpolar regions.

In summary, the solubility of 2-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine is influenced by a variety of factors, making it crucial for researchers to consider solvent selection based on the intended application. As the saying goes, "Like dissolves like," and understanding these dynamics can lead to more successful outcomes in practical applications.

Interesting facts

Interesting Facts about 2-(6,11-Dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine

The chemical compound known as 2-(6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine belongs to a class of compounds often explored for their potential therapeutic applications. Its unique structure offers a fascinating insight into the world of pharmaceutical chemistry.

Therapeutic Potential

This compound is of significant interest in medicinal chemistry due to its association with:

  • Anxiolytic Properties: Compounds containing a benzodiazepine structure are typically noted for their calming effects and ability to reduce anxiety.
  • Neurotransmitter Modulation: It may interact with GABA receptors, leading to increased neuronal inhibition.
  • Drug Development: The compound can serve as a lead structure for creating new medications aimed at treating various psychiatric disorders.

Chemical Characteristics

From a structural perspective, it includes a fused benzodiazepine system, which is crucial for its activity:

  • Fused Ring System: The specific arrangement of atoms in the fused rings contributes to the compound's stability and binding affinity to target receptors.
  • Substituents: The presence of N,N-dimethyl-ethanamine enhances its lipid solubility, affecting how effectively it can cross the blood-brain barrier.

Research Insights

Scientific research has shown that modifications to the benzodiazepine structure can dramatically alter the pharmacological profile of the compound. According to leading pharmacologists, *“Small changes in chemical structure can lead to substantial differences in biological activity.”*

Continued exploration into the pharmacodynamics and pharmacokinetics of this compound could unlock new methods of treatment and enhance our understanding of how similar molecules can be optimized in the future. The synthesis of this compound may involve complex organic reactions, showcasing the intricate art and science of chemical synthesis.