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Tetrabenazine

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Identification
Molecular formula
C19H27NO3
CAS number
58-46-8
IUPAC name
2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine
State
State

Tetrabenazine is typically in a solid state at room temperature and is used in medical settings primarily in tablet form.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
566.20
Boiling point (Kelvin)
839.35
General information
Molecular weight
317.43g/mol
Molar mass
317.4300g/mol
Density
1.1220g/cm3
Appearence

In its pure form, Tetrabenazine appears as a white to slightly yellow crystalline powder. It is soluble in chloroform, slightly soluble in acetone, methanol, and ethanol, and practically insoluble in water.

Comment on solubility

Solubility Characteristics

The compound 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine exhibits interesting solubility traits, which can greatly influence its behavior in various environments.


Key Aspects of Solubility:

  • Polar vs. Non-Polar: This compound is predominantly non-polar due to its extensive hydrocarbon framework. Thus, it is likely to exhibit low solubility in polar solvents like water.
  • Solvent Compatibility: Solubility may be favorable in non-polar solvents such as hexane or toluene, where it can dissolve more readily.
  • Influence of Functional Groups: The presence of methoxy groups (-OCH3) may enhance solubility in suitable solvents by facilitating weak interactions like dipole-dipole and Van der Waals forces.
  • Temperature Effects: Generally, higher temperatures can increase solubility, allowing for better dissolution in the appropriate solvent mediums.

In conclusion, while the solubility of 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine tends to be limited in water, exploring the right chemical context can unveil potential applications in organic or medicinal chemistry.

Interesting facts

Interesting Facts about 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine

This compound, a member of the isoquinoline family, presents a fascinating blend of structural complexity and potential biological activity. With a sophisticated architecture, its design features both dimethoxy and ethyl substituents, which can significantly impact its properties and interactions in various settings.

Here are some notable points about this intriguing compound:

  • Isoquinoline Framework: The compound's unique backbone is derived from isoquinoline, a versatile structure that is frequently observed in various natural products and pharmaceutical agents.
  • Biological Potential: Compounds with similar structures have been studied for their potential in medicinal chemistry, particularly for their roles as antidepressants and antitumor agents.
  • Analogous Compounds: It shares similarities with various alkaloids, including those found in plants such as Papaver somniferum and Berberis, indicating possible pathways for targeting similar biological systems.
  • Synthetic Challenges: The intricate construction of this molecule highlights the challenges associated with synthesizing complex organic compounds, often involving multiple reaction steps and careful optimization to achieve good yields.
  • Research Opportunities: Given its structural elements, this compound is ripe for further exploration, especially in the realms of medicinal chemistry, whereby scientists seek to uncover the mechanisms of action through which these molecular features exert their effects.

In essence, the compound innovatively bridges advanced organic synthesis with potential therapeutic implications. Its exploration may pave the way for new discoveries related to its biological effects and applications!

Synonyms
ISOEMETINE, TETRADEHYDRO-
Purum (Salt/Mix)
GNF-Pf-5190
Amebicide (Salt/Mix)
CHEMBL192858
MEGxp0_002048
SCHEMBL13912579
ACon0_000657
DTXSID80859331
2H-Benzo(a)quinolizine, 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-((1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl)methyl)-
NSC25464
NSC-25464
SW220072-1
1a({3aEthyla9,10adimethoxya1H,2H,3H,4H,6H,7H,11bHa pyrido[2,1aa]isoquinolina2ayl}methyl)a6,7a dimethoxya1,2,3,4atetrahydroisoquinoline
7005-82-5