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Galanthamine hydrobromide

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Identification
Molecular formula
C17H21NO3
CAS number
1953-04-4
IUPAC name
2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,4,5,6,7,11b-hexahydrobenzo[a]quinolizin-5-ium;dibromide
State
State

At room temperature, galanthamine hydrobromide is in a solid state, typically existing as a crystalline powder. It is stable and can be handled as a standard pharmaceutical ingredient under appropriate storage conditions.

Melting point (Celsius)
237.00
Melting point (Kelvin)
510.15
Boiling point (Celsius)
373.15
Boiling point (Kelvin)
646.30
General information
Molecular weight
368.28g/mol
Molar mass
368.2780g/mol
Density
1.3000g/cm3
Appearence

Galanthamine hydrobromide typically appears as a white to slightly off-white crystalline powder. This compound is often used in the context of pharmaceuticals, and its purity and form (powder or crystalline) can be essential for its applications.

Comment on solubility

Solubility of 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,4,5,6,7,11b-hexahydrobenzo[a]quinolizin-5-ium;dibromide

The solubility of the compound 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,4,5,6,7,11b-hexahydrobenzo[a]quinolizin-5-ium;dibromide can be analyzed through various factors:

  • Polarity: This compound contains several polar functional groups due to the presence of nitrogen and oxygen atoms, which typically enhances its solubility in polar solvents.
  • Salt Formation: As a dibromide, it is likely to dissolve well in polar solvents, such as water. The bromide ions can contribute to ionic interactions, improving solubility.
  • Hydrogen Bonding: The presence of methoxy groups may facilitate hydrogen bonding with suitable solvents, further contributing to its solubility profile.

In summary, based on its structure and the underlying chemistry, one might expect 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,4,5,6,7,11b-hexahydrobenzo[a]quinolizin-5-ium;dibromide to have good solubility characteristics, particularly in polar solvents. However, specific solubility data would provide a clearer understanding of its behavior in various environments.

Interesting facts

Interesting Facts About 2-[(6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-2-Ium-1-Yl)Methyl]-3-Ethyl-9,10-Dimethoxy-1,4,5,6,7,11b-Hexahydrobenzo[a]Quinolizin-5-Ium; Dibromide

This compound is a fascinating member of the isoquinoline family, which is known for its rich diversity and medicinal properties. Isoquinolines themselves are alkaloids with a wide array of biological activities, and they often play significant roles in drug discovery and development.

Key Highlights:

  • Structural Complexity: The compound features a multi-cyclic framework, which contributes to its distinctive pharmacological activities. Its intricate structure not only showcases the beauty of organic chemistry but also hints at potential interactions with various biological targets.
  • Bioactivity: Compounds similar to this one have been studied for their potential in treating various conditions, including neurodegenerative diseases, due to their ability to interact with neurotransmitter systems.
  • Dimethoxy Groups: The presence of methoxy groups enhances the compound's lipophilicity, which can improve its membrane permeability and biological efficacy.
  • Dibromide Form: As a dibromide, this compound may offer enhanced stability and solubility characteristics. Bromine atoms can also play a role in the compound's reactivity, making it a valuable synthetic intermediate in further chemical reactions.

Research into compounds like this can yield insights into their effects on cellular signaling and metabolism. Their mechanisms can be quite intricate, often involving multiple pathways, contributing not just to drug discovery, but also to understanding fundamental biochemical processes.

This compound serves as a testament to the complex interplay of chemistry, biology, and pharmacology, highlighting the potential that compounds with such elaborate structures hold for scientific advancement.