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Galanthamine hydrobromide

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Identification
Molecular formula
C17H21NO3.HBr
CAS number
1953-04-4
IUPAC name
2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine;chloride
State
State
At room temperature, galanthamine hydrobromide is typically in a solid state, appearing as a crystalline powder that may vary from white to off-white.
Melting point (Celsius)
246.00
Melting point (Kelvin)
519.15
Boiling point (Celsius)
454.00
Boiling point (Kelvin)
727.15
General information
Molecular weight
368.87g/mol
Molar mass
368.8730g/mol
Density
1.4300g/cm3
Appearence
Galanthamine hydrobromide typically appears as a white to off-white crystalline powder. Due to its hygroscopic nature, it can absorb moisture from the environment.
Comment on solubility

Solubility of 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine;chloride

The solubility of 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine;chloride is an intriguing aspect of this compound's chemistry. Understanding its solubility helps in various applications, including pharmaceutical formulation and chemical synthesis. Here are some key points regarding its solubility:

  • Solvent Interaction: The presence of multiple methoxy groups in the structure tends to increase the solubility in polar solvents such as water and alcohols.
  • Ionic Nature: As a chloride salt, it is generally more soluble in polar solvents due to the ionic interactions that facilitate dissolution.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, enhancing the dissolution process in hotter solvents.
  • pH Sensitivity: The ionization of the compound can vary based on pH, affecting its solubility significantly; thus, it might be better soluble in acidic or basic conditions.

In conclusion, while specific solubility data for this complex compound is not readily available, its structural features suggest it may be expected to show better solubility in polar solvents, especially under favorable conditions. As always, laboratory testing is recommended for precise solubility determinations.

Interesting facts

Interesting Facts about 2-[(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-1-yl)methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine; Chloride

This complex compound belongs to a class of chemicals known as isoquinolines, which have fascinating biological activities. Isoquinolines have been extensively studied for their potential in medicinal chemistry due to their ability to interact with various biological targets.

Key Highlights:

  • Medicinal Potential: Compounds containing isoquinoline structures have shown promise in drug discovery and development, particularly in the treatment of neurological disorders.
  • Bioactivity: The presence of methoxy groups in this compound suggests increased lipophilicity, which can enhance the compound's ability to penetrate biological membranes, potentially leading to higher bioactivity.
  • Synthetic Routes: The synthesis of such complex molecules often involves multiple reaction steps, showcasing the ingenuity and creativity of organic chemists. Techniques such as stock's reaction or multicomponent reactions might be used in the synthetic pathway.
  • Cationic Character: The quaternary ammonium nature of the isoquinoline contributes to its positive charge, which can influence the compound's reactivity and interaction with biological targets.

Scientists are constantly exploring the structural variations in isoquinoline derivatives to uncover new pharmacological applications. The versatility of this compound makes it a subject of great interest in both synthetic organic chemistry and medicinal research.

Moreover, the unique features of its structural components make it an exciting candidate for studies in molecular recognition and receptor binding, opening avenues for further research based on its interactions at the molecular level.

Synonyms
NS00126779