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Dexamethasone 21-pentanoate

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Identification
Molecular formula
C27H36F2O5
CAS number
14899-36-6
IUPAC name
[2-(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] pentanoate
State
State

At room temperature, dexamethasone 21-pentanoate typically exists as a solid. It can appear as a crystalline powder and should be stored in a dry environment, away from light and moisture to maintain its stability and efficacy.

Melting point (Celsius)
245.00
Melting point (Kelvin)
518.15
Boiling point (Celsius)
588.60
Boiling point (Kelvin)
861.75
General information
Molecular weight
460.58g/mol
Molar mass
460.5380g/mol
Density
1.4100g/cm3
Appearence

Dexamethasone 21-pentanoate is typically a white to off-white crystalline powder or solid. It is often found in its pure form for synthesis or in pharmaceutical preparations. Its crystalline characteristics make it distinguishable under a microscope.

Comment on solubility

Solubility of [2-(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] pentanoate

The solubility of this compound, with the molecular formula C27H36F2O5, is a fascinating topic to explore, particularly due to its complex structure. Various factors can influence the solubility of such a compound:

  • Polarity: The presence of fluorine and hydroxyl groups can enhance polarity, potentially affecting solubility in polar solvents like water.
  • Hydrophobic and Lipophilic Characteristics: The large hydrocarbon structure may confer hydrophobic properties, which could limit solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl group allows for hydrogen bonding, which may improve solubility in certain organic solvents.

It is important to note that the compound's solubility may be significantly different in various solvents. In general, it may exhibit the following solubility behavior:

  1. High Solubility: In organic solvents such as ethanol or methanol due to favorable interactions.
  2. Moderate Solubility: In less polar organic solvents, where the balance of hydrophobic and polar characteristics comes into play.
  3. Low Solubility: In water, due to its larger non-polar hydrocarbon structure dominating.

In conclusion, the solubility of [2-(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] pentanoate reflects a balance of its diverse structural features. Understanding this can lead to better applications in pharmaceuticals and organic chemistry.

Interesting facts

Interesting Facts about 2-(6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl Pentanoate

This compound exhibits a unique structure owing to its complex arrangement of functional groups and the fluorinated moieties, making it an important molecule in pharmaceutical chemistry. Here are some fascinating insights:

  • Pharmaceutical Relevance: This compound is likely to play a role in medicinal chemistry, especially in the development of drugs with anti-inflammatory or anti-cancer properties due to the presence of various functional groups that can interact with biological systems.
  • Fluorine Influence: The presence of fluorine atoms significantly alters the pharmacokinetic properties of organic compounds. Fluorinated drugs often exhibit improved metabolic stability and enhanced binding to biological targets.
  • Steroidal Framework: The cyclopenta[a]phenanthrene structure suggests that this compound is related to steroid-likesubstances, which are fundamental in many biological processes such as hormone regulation and signaling.
  • Complexity Equals Efficacy: Compounds with intricate structures, like this one, often show higher efficacy and specificity in target interactions compared to simpler molecules. This complexity may provide an exciting platform for further drug design.
  • Research Potential: Due to its multifaceted nature, this compound may serve as a valuable subject for further studies, potentially leading to novel therapeutic agents or enhancing existing treatments.

As a chemistry student or scientist, one can appreciate the intricate balance between structure and activity in such compounds. Understanding the nuances for the interactions and effects that different substituents have on biological activity can pave the way for groundbreaking discoveries in therapeutic applications.

Synonyms
SCHEMBL13158