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Dexamethasone 21-acetate

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Identification
Molecular formula
C24H31F2O6
CAS number
1177-87-3
IUPAC name
[2-(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 2,2-dimethylpropanoate
State
State

At room temperature, Dexamethasone 21-acetate is in a solid state, often found as a crystalline powder.

Melting point (Celsius)
255.00
Melting point (Kelvin)
528.15
Boiling point (Celsius)
585.80
Boiling point (Kelvin)
858.95
General information
Molecular weight
472.52g/mol
Molar mass
472.5230g/mol
Density
1.3000g/cm3
Appearence

Dexamethasone 21-acetate typically appears as a white to off-white crystalline powder. It is generally odorless.

Comment on solubility

Solubility of the Compound

The solubility of the compound [2-(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 2,2-dimethylpropanoate, with the chemical formula C24H31F2O6, can present unique characteristics due to its complex structure and functional groups.

Factors Influencing Solubility

The solubility of this compound can be influenced by several factors:

  • Hydrophilicity vs. Hydrophobicity: The presence of hydroxyl (–OH) groups generally increases solubility in polar solvents, while the bulky aliphatic chains tend to enhance hydrophobic interactions.
  • Temperature: Higher temperatures typically increase solubility for many compounds, allowing for better dissolution of materials.
  • pH Levels: The solubility may also vary with changes in pH, particularly due to potential ionization of functional groups in different environments.

Expected Solubility Behavior

Given its structure, it is reasonable to anticipate:

  • A moderate solubility in organic solvents such as ethanol or acetone due to the non-polar hydrocarbon portions.
  • Limited solubility in water, primarily due to the hydrophobic regions prevailing over any polar aspects.

In essence, the solubility of this compound is a fascinating interplay of its chemical structure and external conditions. Understanding these nuances can aid in various applications, from formulation development to pharmacokinetic evaluations.

Interesting facts

Interesting Facts About 2-(6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl 2,2-dimethylpropanoate

This compound represents a fascinating blend of complex organic chemistry and medicinal potential. Its structure reveals a rich framework of functionality, primarily driven by the incorporation of a cyclopenta[a]phenanthrene core. Here are some noteworthy elements of this compound:

  • Fluorine Substitution: The presence of fluorine atoms is not just for decoration—fluorinated compounds often exhibit enhanced biological activity and improved metabolic stability. This makes the compound potentially advantageous in pharmaceutical applications.
  • Hydroxyl Group: The –OH group at position 11 suggests the compound may act as a weakly polar functional group, which can influence solubility and reactivity. Hydroxyl groups are also known for participating in hydrogen bonding, which can enhance biological interactions.
  • Trimethyl Groups: The presence of trimethyl substitutions implies steric bulk, which may affect how the compound interacts with biological targets, possibly altering its pharmacokinetic properties.
  • Synthetic Interest: This compound could serve as a valuable lead in synthetic chemistry for developing new therapeutic agents. Its intricate structure provides ample opportunities for further modifications, allowing chemists to explore structure-activity relationships (SAR) in-depth.

In the words of Nobel laureate Ahmed Zewail, "Chemistry is not just an academic discipline—it is the backbone of our everyday lives." This compound exemplifies how intricate chemistry can lead to advancements in medicine and offers a testament to the creativity and innovation inherent in chemical science.


As scientists continue to explore the properties of this compound, they pave the way for potential applications in drug development, showcasing the ability of complex organic compounds to influence human health and well-being.