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Dexamethasone acetate

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Identification
Molecular formula
C24H31FO6
CAS number
1177-87-3
IUPAC name
[2-(6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 2,2-dimethylpropanoate
State
State

At room temperature, dexamethasone acetate is in a solid state. It is stable under standard conditions when stored properly in a dry, cool environment.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
462.52g/mol
Molar mass
462.5150g/mol
Density
1.3100g/cm3
Appearence

Dexamethasone acetate appears as a white to off-white crystalline powder. It lacks any significant odor and is characterized by its crystalline structure, contributing to its solid form at room temperature.

Comment on solubility

Solubility of [2-(6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 2,2-dimethylpropanoate (C24H31FO6)

The solubility of the compound C24H31FO6, known for its complex structure, can be influenced by various factors, making it a topic of interest. Its solubility properties can be characterized by the following key points:

  • Solvent Interaction: The presence of hydroxy groups can enhance hydrogen bonding with polar solvents, thereby increasing the likelihood of solubility in such media.
  • Polarity: Due to the combination of fluorine atoms and oxygen functional groups, this compound may exhibit varying degrees of polarity, impacting its solubility in organic versus aqueous solvents.
  • Temperature Effects: Generally, an increase in temperature can lead to enhanced solubility for many compounds, and this may apply to C24H31FO6 as well.
  • pH Dependence: The solubility could also vary with changes in pH, especially because of the presence of acidic or basic functional groups within the molecular structure.
  • Practical Applications: Understanding the solubility is vital for applications in pharmaceutical formulations, where solubility can drastically affect bioavailability and efficacy.

In conclusion, while the specific solubility data for this compound may not be readily available without empirical testing, its structural features suggest that solubility would be influenced by the factors mentioned above, making it both a complex and intriguing area of study.

Interesting facts

Interesting Facts about 2-(6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl 2,2-dimethylpropanoate

This intricate compound, known for its multifaceted structure, belongs to a class of chemical compounds that combine significant biological and pharmaceutical interests. Here are some captivating insights:

  • Natural Compound Inspired: Its structure draws inspiration from natural steroid frameworks, which are pivotal in various biological processes.
  • Pharmacological Potential: The presence of hydroxyl groups in the compound may enhance its interaction with biological systems, making it a candidate for drug development, particularly in anti-inflammatory and anti-cancer research.
  • Fluorine Incorporation: The difluoro substitutions not only increase the compound's lipophilicity but also potentially enhance its metabolic stability, which can be crucial for pharmaceutical efficacy.
  • Functionalization: The *2-oxo-ethyl* and *2,2-dimethylpropanoate* groups further modify the compound's properties, which can impact its solubility and reactivity, reflecting a careful design aimed at optimizing performance.

The compound's complex composition, with its unique arrangement and multiple functional groups, sets the stage for extensive research. As noted by a leading chemist, “The interplay between structure and function in organic compounds can unlock groundbreaking therapeutic avenues.”
Understanding and exploring such compounds not only enriches our knowledge of chemistry but also enhances our ability to develop innovative solutions in medicine.

Synonyms
Locacorten
6,9-difluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate
SCHEMBL1302813
6.Alpha.,9.alpha.-Difluoro-16.alpha.-methylprednisolone 21-pivalate
CHEMBL1982638
DTXSID80859694
NCI60_000182
6.alpha.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione 21-pivalate
6|A,9-Difluoro-11|A,17,21-trihydroxy-16|A-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate)
Pregna-1,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-
Pregna-1,20-dione, 6.alpha.,9-difluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-, 21-pivalate