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Fluocortolone caproate

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Identification
Molecular formula
C29H41FO5
CAS number
1524-88-5
IUPAC name
[2-[(6S,11S,14S,16R)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] hexanoate
State
State

Fluocortolone caproate is typically in a solid state at room temperature. It is stable under normal conditions and is used in topical formulations as an anti-inflammatory agent.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
488.64g/mol
Molar mass
0.0000g/mol
Density
1.2200g/cm3
Appearence

Fluocortolone caproate typically appears as a white to off-white crystalline powder. It is odorless and has a characteristic crystalline texture. The compound is often found in micronized form for pharmaceutical applications.

Comment on solubility

Solubility of [2-[(6S,11S,14S,16R)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] hexanoate

When discussing the solubility of complex organic compounds such as [2-[(6S,11S,14S,16R)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] hexanoate, it is important to consider various factors that influence its behavior in different solvents. Here are some key points:

  • Polarity: The overall polarity of this compound may affect its solubility in polar versus nonpolar solvents. Given its structural complexity and the presence of functional groups, solubility in aqueous solutions may be limited.
  • Hydrophobic Interactions: The extensive hydrocarbon-like sections of the molecule suggest that it may be more soluble in organic solvents such as ethanol, methanol, or chloroform.
  • Functional Groups: The presence of hydroxyl and oxo groups can enhance intermolecular hydrogen bonding, thus aiding solubility in polar solvents but potentially restricting it in nonpolar environments.

In summary, the solubility of [2-[(6S,11S,14S,16R)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] hexanoate is likely to be enhanced in organic solvents due to its nonpolar characteristics, while solubility in water may be quite limited due to its substantial hydrophobic molecular structure. As always, empirical testing would provide the most reliable insight into its solubility profile.

Interesting facts

Exploring the Compound: 2-[(6S,11S,14S,16R)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] hexanoate

This complex compound belongs to the class of steroid derivatives, showcasing the intricate nature of organic chemistry. Derived from steroidal structures, compounds like this one often exhibit a variety of biological activities. Here's a closer look at some fascinating aspects:

  • Structure Complexity: Its multi-ring structure is reminiscent of various naturally occurring steroids, highlighting the diverse structural possibilities within steroid chemistry.
  • Fluorination Impact: The presence of fluorine (in the form of a "6-fluoro" group) can enhance biological activity and metabolic stability, making compounds with fluorine substitutions interesting for pharmacological applications.
  • Hydroxyl Functionality: The hydroxy group at the 11-position adds potential functional properties that can contribute to its affinity for biological targets, making it a candidate for drug development.
  • Applications: Compounds like this one are often investigated for their potential roles in therapies related to hormonal imbalances or cancer treatment due to their steroidal nature.

As a chemistry student, it's fascinating to see how such a complex molecule can serve as a bridge between natural products and synthetic chemistry. Its intricate design invites discussion and exploration, raising questions about how the various functional groups interact and influence biological activity. Indeed, the pursuit of understanding these interactions could pave the way for groundbreaking therapeutic advancements.

Quote from renowned chemist: "Molecules like these remind us that chemistry is an intricate dance of atoms and bonds, each step leading us closer to new discoveries."