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Fluocinolone acetonide

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Identification
Molecular formula
C24H30F2O6
CAS number
67-73-2
IUPAC name
[2-[(6S,11S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, fluocinolone acetonide is in a solid state, specifically as a powder.

Melting point (Celsius)
274.00
Melting point (Kelvin)
547.15
Boiling point (Celsius)
396.00
Boiling point (Kelvin)
669.15
General information
Molecular weight
452.49g/mol
Molar mass
452.4930g/mol
Density
1.4000g/cm3
Appearence

Fluocinolone acetonide is a white to off-white crystalline powder. It is odorless and has a very fine, powdery texture. When observed under specific lighting, it might exhibit a slight luster due to its crystalline nature.

Comment on solubility

Solubility of the Compound

The solubility of 2-[(6S,11S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate can be influenced by a variety of factors:

  • Polarity: The presence of hydroxyl groups often increases a compound's polarity, enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: This compound can partake in hydrogen bonding due to its hydroxyl groups, which may further improve solubility in some environments.
  • Solvent Interaction: Depending on the specific solvent used, various interactions (such as dipole-dipole or van der Waals forces) can affect solubility.
  • Temperature: Generally, increased temperature can improve solubility for many compounds, but exceptions may apply.
  • Concentration: As with many compounds, excessive concentration may lead to precipitation even if the compound is overall soluble.

According to qualitative assessments, one might say, “The better the interaction between solute and solvent, the greater the solubility.” Thus, understanding the factors outlined above is essential for predicting and optimizing the solubility of this complex compound.

Interesting facts

Interesting Facts About 2-[(6S,11S,14S,16R,17R)-6-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl Acetate

This chemically intricate compound is noteworthy for its complex structure and potential biological significance. Below are some fascinating aspects to consider:

  • Structural Complexity: The compound exhibits stereochemistry characterized by multiple chiral centers and a distinctive cyclopenta[a]phenanthrene backbone. This configuration plays a critical role in its biological activity.
  • Fluorine Substitution: The presence of a fluorine atom is prominent in its structure, which often enhances metabolic stability and bioactivity. Fluorinated compounds are increasingly popular in medicinal chemistry for developing pharmaceuticals.
  • Hydroxyl Groups: It contains hydroxyl groups (–OH) at specific positions contributing to its pharmacological properties. Hydroxylation can increase solubility and influence the compound's interactions with biological targets.
  • Potential Therapeutic Applications: While the specific applications of this compound require deeper investigation, compounds of a similar nature have been explored for their roles in areas such as cancer treatment, hormone regulation, and anti-inflammatory responses.
  • Research and Development: Chemists are continually researching compounds like this to understand their mechanisms of action and to develop derivatives with enhanced efficacy or reduced side effects.

As noted by researchers in the field, "Understanding the subtleties of compound interactions at a molecular level can unveil unprecedented therapeutic strategies." This statement encapsulates the ongoing excitement in the study of compounds such as this complex acetate.

The exploration of 2-[(6S,11S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate showcases not only the beauty of chemical diversity but also the profound impact that chemical innovations can have on human health.

Synonyms
NCGC00185748-01