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Fluocinolone acetonide

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Identification
Molecular formula
C24H30F2O7
CAS number
67-73-2
IUPAC name
[2-[(6S,17S)-16-acetoxy-6-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, Fluocinolone acetonide is in a solid state. It is typically found in its bulk powder form for pharmaceutical formulation purposes.

Melting point (Celsius)
272.00
Melting point (Kelvin)
545.15
Boiling point (Celsius)
529.50
Boiling point (Kelvin)
802.65
General information
Molecular weight
452.50g/mol
Molar mass
452.4960g/mol
Density
1.2809g/cm3
Appearence

Fluocinolone acetonide is a white to off-white crystalline powder. It is odorless and has a very faint chemical odor. Due to its crystalline nature, it is not hygroscopic and does not readily absorb moisture from the air, maintaining its stability under normal conditions.

Comment on solubility

Solubility of the Compound

The compound 2-[(6S,17S)-16-acetoxy-6-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate with the chemical formula C24H30F2O7 presents interesting solubility characteristics:

  • Polar Nature: Due to the presence of multiple hydroxyl groups (–OH) and ester functionalities, this compound likely exhibits polar characteristics, which can enhance its solubility in polar solvents.
  • Solvent Compatibility: It may dissolve readily in alcohols, acetone, and other polar solvents, whereas its solubility in non-polar solvents such as hexane is expected to be low.
  • Influence of Fluorine: The inclusion of a fluorine atom can alter the solubility behavior, potentially affecting the hydrophobicity and making it less soluble in aqueous solutions.
  • Temperature Dependence: As with many organic compounds, solubility may vary with temperature; increased temperatures can often lead to higher solubility.

In conclusion, understanding the solubility of this compound is crucial for its applications in various fields, from pharmacology to material science. It demonstrates that the interplay of molecular structure and solvent interactions profoundly impacts solubility characteristics.

Interesting facts

Interesting Facts About 2-[(6S,17S)-16-acetoxy-6-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate

This complex chemical compound belongs to a class of organic molecules known for their multifaceted structure and biological activity. Its intricate design allows it to interact with various biochemical pathways, making it a subject of interest in both medicinal chemistry and pharmacology.

Key Features:

  • Fluorine Substitution: The presence of fluorine in its structure enhances the compound's biological activity and metabolic stability, often leading to increased potency in pharmaceutical applications.
  • Hydroxyl Groups: Featuring hydroxyl (-OH) groups, which can serve as hydrogen bond donors, this compound may exhibit strong interaction with biological targets, influencing its efficacy as a therapeutic agent.
  • Acetyloxy Group: The acetoxy functional group can affect the solubility and reactivity of the compound, suggesting interesting profiles for drug formulation and delivery systems.

The compound's synthesis might involve complex organic reactions, often utilizing a series of protective group techniques to ensure successful assembly of its many functional groups. As a result, students and researchers alike delve into the methodologies of creating such multi-faceted molecules.

According to noted chemists: "The beauty of organic chemistry lies in the complexity that arises from simple building blocks. Understanding compounds like this can unveil pathways to novel therapeutics."

In summary, this compound exemplifies the advances in synthetic organic chemistry and the potential for discovering new medical treatments. Its structure offers a rich playground for exploration in drug design, making it a fascinating subject for both chemists and biologists alike.