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Halometasone acetate

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Identification
Molecular formula
C22H27ClF2O5
CAS number
50256-47-0
IUPAC name
[2-[(6S,9R,10S,11S,13S,16R,17R)-16-chloro-6,9-difluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, halometasone acetate is a solid compound. It is stable under normal conditions of use and storage, though it should be protected from excessive moisture and heat to maintain its integrity.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
472.50
Boiling point (Kelvin)
745.65
General information
Molecular weight
521.90g/mol
Molar mass
521.3750g/mol
Density
1.5000g/cm3
Appearence

Halometasone acetate appears as a white to off-white crystalline powder. It is practically odorless and generally has a smooth texture.

Comment on solubility

Solubility of [2-[(6S,9R,10S,11S,13S,16R,17R)-16-chloro-6,9-difluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate (C22H27ClF2O5)

The solubility behavior of the compound can be influenced by various factors, making it essential to consider these aspects for practical applications. Key points to note include:

  • Polarity: The presence of both hydrophilic (-OH) and hydrophobic (aromatic rings) functional groups can lead to a complex solubility profile. Generally, compounds with more polar functional groups tend to be more soluble in polar solvents.
  • Solvent Interaction: The compound's solubility in water, organic solvents, or mixed solvents can vary significantly. For example, it may exhibit reasonable solubility in ethanol and dimethyl sulfoxide (DMSO) but be less soluble in non-polar solvents.
  • Concentration Variability: At higher concentrations, solubility can be affected by the compound’s propensity to form aggregates or precipitates, influencing its bioavailability.
  • pH Dependence: The solubility might also be pH-dependent, particularly due to the presence of acidic or basic groups which ionize under different pH conditions.

In summary, while this compound's solubility is multifaceted, understanding the interaction between its structural characteristics and the solvent environment is crucial. As a final note, remember that "the right solvent can make a world of difference!" This emphasizes the importance of proper selection for enhancing solubility and overall efficacy.

Interesting facts

Interesting Facts about 2-[(6S,9R,10S,11S,13S,16R,17R)-16-chloro-6,9-difluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl Acetate

This compound, with its complex structure, showcases the fascinating world of synthetic organic chemistry. Its intricate configuration, specifically the stereochemistry, leads to interesting implications in biological activity and drug design. Here are some key points to consider:

  • Biological Relevance: Compounds that share similar structures often play crucial roles in pharmacology, potentially serving as therapeutic agents. Understanding how modifications to the structure affect activity can help in drug development.
  • Fluorine Substitution: The presence of fluorine atoms in the structure contributes to increased metabolic stability. Fluorinated compounds are of particular interest in medicinal chemistry due to their unique properties.
  • Stereochemistry: The specified stereochemistry implies that this compound may exhibit specific interactions within biological systems, influencing its efficacy as a drug.
  • Functional Groups: The dihydroxy and acetate functionalities are critical for the compound's reactivity and could play a significant role in its mechanism of action.

The synthesis of such compounds often involves multi-step reactions which challenge chemists to explore innovative methodologies. As highlighted in a famous quote by Jean-Marie Lehn, "Molecular machines will challenge our current understanding of information processing, and will bring forth innovative solutions." This compound exemplifies those innovative chemical designs that have potential for high-impact applications.


Overall, the exploration of this compound not only expands our understanding of complex organic structures but also opens new avenues in modern medicinal chemistry.