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Fluocinolone acetonide

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Identification
Molecular formula
C24H30F2O6
CAS number
66734-13-6
IUPAC name
[2-[(6S,9R,11S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2,2-dimethylpropanoate
State
State

At room temperature, fluocinolone acetonide is in a solid state.

Melting point (Celsius)
273.50
Melting point (Kelvin)
546.60
Boiling point (Celsius)
405.70
Boiling point (Kelvin)
678.90
General information
Molecular weight
452.49g/mol
Molar mass
452.4900g/mol
Density
1.2600g/cm3
Appearence

Fluocinolone acetonide is typically found as a white to slightly yellow crystalline powder.

Comment on solubility

Solubility of the Compound

The solubility of the compound 2-[(6S,9R,11S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2,2-dimethylpropanoate can be influenced by several factors due to its complex structure.


  • Polarity: The presence of hydroxy groups may enhance the compound's potential solubility in polar solvents like water.
  • Functional Groups: Functional groups such as esters and ketones can lead to varied solubility profiles depending on the solvent used.
  • Hydrophobic Regions: The large hydrocarbon portions of the molecule may also make it more soluble in non-polar solvents.

Overall, the solubility of this compound is likely to be moderate, exhibiting different characteristics in various solvents. It's essential to consider the dielectric constants and the nature of potential solvents when predicting solubility. As with many organic compounds, the structural complexity can result in unique behavior, making empirical solubility data invaluable for practical applications.

Interesting facts

Interesting Facts about 2-[(6S,9R,11S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2,2-dimethylpropanoate

This compound, with its complex structure, highlights the intriguing world of synthetic organic chemistry and pharmaceutical development. Here are some fascinating aspects to consider:

  • Stereochemistry: The compound features several chiral centers, indicated by its stereochemical descriptors (e.g., 6S, 9R, 11S). This stereochemistry plays a crucial role in determining the biological activity and pharmacokinetics of the molecule.
  • Fluorination: The presence of fluorine atoms enhances the metabolic stability and lipophilicity of the compound, influencing its behavior in biological systems. Fluorinated compounds are widely utilized in medicinal chemistry owing to their improved target specificity.
  • Applications: The structural components suggest potential utility in developing therapeutic agents, possibly for hormonal modulation or cancer treatment. These types of compounds are often investigated as analogues of natural steroids.
  • Structural Complexity: The intricate multi-cyclic framework of this compound is a testament to synthetic chemists' ingenuity in constructing complex molecules, which often serve as a starting point in drug design.
  • Functional Groups: With multiple functional groups, including hydroxyl and carbonyl groups, this compound exhibits versatile reactivity, allowing for further modifications to enhance its therapeutic potential.

In the words of prominent chemists, *“Molecules are the architecture of life; understanding their structure is key in unlocking their potential.”* This compound embodies that essence, bridging synthetic challenges with the hope of therapeutic advancements.


As research continues in this field, compounds like this may lead to groundbreaking discoveries and improved treatments for various diseases, proving that the complexities of chemical compounds are both a challenge and an opportunity for scientific innovation.

Synonyms
DTXSID7049005
[2-[(6S,9R,11S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate
NCGC00022408-03
CHEMBL2359842
Tox21_113499
CAS-2002-29-1