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Topotecan

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Identification
Molecular formula
C23H23N3O5
CAS number
123948-87-8
IUPAC name
2-(7-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaen-2-yloxy)ethyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate
State
State

At room temperature, Topotecan is typically found as a solid.

Melting point (Celsius)
213.00
Melting point (Kelvin)
486.00
Boiling point (Celsius)
307.00
Boiling point (Kelvin)
580.00
General information
Molecular weight
421.42g/mol
Molar mass
421.4200g/mol
Density
1.4700g/cm3
Appearence

Topotecan is a pale yellow to greenish yellow solid.

Comment on solubility

Solubility of 2-(7-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaen-2-yloxy)ethyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate

The solubility of the compound 2-(7-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaen-2-yloxy)ethyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate can be rather complex, owing to its significant structural intricacies. Several factors can influence its solubility:

  • Ionic Nature: The presence of the dimethyl-ammonium moiety implies a potential for ionic interactions, enhancing solubility in polar solvents.
  • Hydrogen Bonding: The 4-hydroxy-4-oxo-but-2-enoate segment may contribute to hydrogen bonding, which can either facilitate or hinder solubility depending on the solvent used.
  • Hydrophobic Regions: The tricyclic structure introduces hydrophobic characteristics, making the compound less soluble in water, but potentially soluble in organic solvents.

In summary, the solubility is expected to be:

  • Higher in polar solvents due to ionic interactions.
  • Moderate in less polar solvents because of hydrophobic sites.
  • Lower in non-polar solvents given the presence of polar functionalities.

It is essential to conduct empirical tests to determine the exact solubility, as the theoretical predictions may vary due to environmental factors such as temperature and pH conditions. Understanding the solubility profile is crucial for applications in pharmaceutical formulations and chemical synthesis.

Interesting facts

Interesting Facts about 2-(7-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaen-2-yloxy)ethyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate

This compound is a fascinating example of complex molecular architecture and diverse functional properties. Here are some intriguing aspects:

  • Structural Diversity: This compound exhibits a unique tricyclic structure that is emblematic of intricate organic chemistry. The presence of nitrogen in its cyclic framework adds a layer of complexity typically associated with alkaloids.
  • Biological Relevance: Compounds with similar structures have been researched for their potential biological activities, including roles in drug development and medicinal chemistry.
  • Reaction Pathways: The presence of functional groups such as the dimethylammonium and the hydroxy-oxo moiety suggests potential reactivity, making it a candidate for various chemical transformations.
  • Applications: Due to its intricate structure, this compound could find applications in materials science, pharmaceuticals, and as a tool in biochemical assays, influencing fields such as drug delivery systems.

The study of such compounds broadens our understanding of chemical interactions and paves the way for innovative applications. In the words of a renowned chemist, "Nature knows no bounds in its creativity, and so should we in our explorations." Thus, exploring the intricacies of this compound not only enhances chemistry knowledge but also inspires future research directions.