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Bromazepam

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Identification
Molecular formula
C14H10BrN3O
CAS number
1812-30-2
IUPAC name
2-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-1-yl]ethyl-diethyl-ammonium;chloride
State
State

At room temperature, bromazepam is usually in solid state.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
240.00
Boiling point (Kelvin)
513.15
General information
Molecular weight
316.56g/mol
Molar mass
316.5600g/mol
Density
1.3000g/cm3
Appearence

Bromazepam is typically found as a white to off-white crystalline powder or as colorless crystals.

Comment on solubility

Solubility of 2-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-1-yl]ethyl-diethyl-ammonium;chloride

The solubility of a compound such as 2-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-1-yl]ethyl-diethyl-ammonium;chloride is an important characteristic that influences its application in various chemical and pharmaceutical processes. This compound, being a quaternary ammonium salt, typically exhibits a few key traits with regards to solubility:

  • High Water Solubility: Quaternary ammonium salts generally have increased solubility in water due to their ionic nature, which facilitates interaction with polar solvents.
  • Dependence on pH: The solubility can be influenced by the pH of the solution, as the ionic form is more soluble in neutral to slightly acidic conditions.
  • Solvent Compatibility: While it is likely soluble in water, the compound may also dissolve in polar organic solvents such as ethanol or methanol, albeit to differing extents.

It is noteworthy that solubility can be affected by temperature, where an increase in temperature often enhances the solubility of ionic compounds. Understanding these solubility characteristics is crucial for optimizing the use of 2-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-1-yl]ethyl-diethyl-ammonium;chloride in practical applications.

Interesting facts

Interesting Facts about 2-[7-bromo-2-oxo-5-(2-pyridyl)-3H-1,4-benzodiazepin-1-yl]ethyl-diethyl-ammonium;chloride

This compound belongs to the class of benzodiazepines, which are known for their psychoactive properties. Benzodiazepines are frequently used in medicine for their sedative, anxiolytic, and muscle relaxant effects. The specific structure of this compound presents some fascinating features:

  • Structural Complexity: The presence of both a benzodiazepine core and a pyridine ring indicates potential for interesting interactions at the molecular level. This adds complexity to its pharmacological profile.
  • Halogenation Impact: The substitution of bromine at the 7-position of the benzodiazepine ring can enhance the compound's biological activity, potentially affecting its affinity for neurotransmitter receptors.
  • Quaternary Ammonium Component: The diethylammonium group may contribute to the compound's solubility in aqueous environments, impacting its pharmacokinetics and mechanism of action.
  • Research Potential: Given its unique structure, this compound may represent a valuable subject for research into novel anxiolytics or antidepressants, particularly in exploring how structural variations affect efficacy and safety.

As a chemistry student, recognizing the implications of such structures can lead to insights into drug design and development. The combination of different pharmacophores allows chemists to predict interactions and reactions, fostering innovation in medicinal chemistry.

In the words of renowned chemist Yuan T. Lee, "The beauty of chemistry lies in the exploration of how simple changes can lead to dramatic shifts in properties and applications." This compound exemplifies that statement perfectly, showcasing the intricate balance between structure and function in pharmaceutical chemistry.

Synonyms
3966-84-5
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-bromo-1-(2-diethylamino)ethyl-5-(2-pyridyl)-, hydrochloride