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Clomipramine Hydrochloride

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Identification
Molecular formula
C19H24Cl2N2
CAS number
17321-77-6
IUPAC name
[2-(7-chloro-1H-indol-3-yl)-1-methyl-ethyl]ammonium;chloride
State
State

At room temperature, clomipramine hydrochloride is a solid in crystalline form.

Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
287.00
Boiling point (Kelvin)
560.15
General information
Molecular weight
351.30g/mol
Molar mass
351.2960g/mol
Density
1.2260g/cm3
Appearence

Clomipramine hydrochloride appears as a white or slightly off-white crystalline powder. It is typically odorless and has a bitter taste.

Comment on solubility

Solubility of [2-(7-chloro-1H-indol-3-yl)-1-methyl-ethyl]ammonium;chloride

The solubility of the compound [2-(7-chloro-1H-indol-3-yl)-1-methyl-ethyl]ammonium chloride can be assessed through various factors affecting ionic compounds. Being a quaternary ammonium salt, its solubility is particularly noteworthy due to its ionized state in solution.

Factors Influencing Solubility:

  • Polarity: The chloride ion contributes to greater solubility in polar solvents, such as water.
  • Ionic Nature: Presence of ionic bonds indicates a tendency to dissolve in polar solvents, aligning with the general behavior of salts.
  • Hydration Energy: The degree to which the ions attract water molecules affects how well they will dissolve.

This compound is expected to demonstrate good solubility in water because chloride salts typically have favorable solubility characteristics. Furthermore, the structural features of the indole moiety could introduce hydrophobic interactions, suggesting that while the compound may be soluble, the rate could vary depending on temperature and concentration.

In conclusion, the presence of the ammonium group skews the solubility favorably towards aqueous environments, making it a compound of interest for applications requiring solubility in biological and chemical contexts.

Interesting facts

Interesting Facts about [2-(7-chloro-1H-indol-3-yl)-1-methyl-ethyl]ammonium;chloride

This unique compound, commonly referred to in its more digestible name, showcases intriguing properties that are significant in various fields of research and application. Here are some interesting facts:

  • Pharmacological Potential: This compound is often analyzed for its potential role as a pharmaceutical agent. The indole structure is well-known in medicinal chemistry, as many compounds derived from indole exhibit biological activity, including anti-cancer effects.
  • Chlorinated Components: The presence of chlorine in the structure contributes to its reactivity and biological impact. Chlorination is a common strategy in drug design to enhance the pharmacokinetics of a compound.
  • Ammonium Salt Form: Being an ammonium salt, this compound can exhibit different solubility and stability properties compared to its free base form, which can be advantageous in formulation development.
  • Indole Derivative: As a derivative of indole, this compound integrates into a rich family known for diverse functionalities, making it a popular subject in organic synthesis.
  • Research Significance: The synthetic routes and modifications leading to this compound are of particular interest among chemists, providing a pathway to explore new compounds and reactions that could yield even more biologically active materials.

In conclusion, the exploration of [2-(7-chloro-1H-indol-3-yl)-1-methyl-ethyl]ammonium;chloride not only highlights the complexities of organic and medicinal chemistry but also emphasizes the importance of structural modifications in drug development. As researchers continue to uncover its properties, this compound stands as a beacon for further scientific inquiry.

Synonyms
3-(2-Aminopropyl)-7-chloroindole hydrochloride
1013-48-5
INDOLE, 3-(2-AMINOPROPYL)-7-CHLORO-, HYDROCHLORIDE