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Amikacin iodide

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Identification
Molecular formula
C22H31ClIN5O2S
CAS number
37517-27-8
IUPAC name
2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-diethyl-methyl-ammonium;iodide
State
State

At room temperature, Amikacin iodide is typically a solid. It remains stable under recommended storage conditions and should be handled to prevent degradation from environmental factors such as light and moisture.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
429.50
Boiling point (Kelvin)
702.65
General information
Molecular weight
387.25g/mol
Molar mass
387.2500g/mol
Density
1.3500g/cm3
Appearence

Amikacin iodide typically appears as a white to off-white crystalline solid. It is often available in powdered form, intended for dissolution in a suitable solvent before administration or further use.

Comment on solubility

Solubility of 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-diethyl-methyl-ammonium; iodide

The solubility of 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-diethyl-methyl-ammonium iodide can be characterized as follows:

  • Water Solubility: This compound is generally regarded as poorly soluble in water due to its complex structure and the presence of the bulky ammonium group, which may hinder interaction with water molecules.
  • Organic Solvents: It may exhibit better solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), or acetone. The non-polar characteristics of these solvents can facilitate solvation of the compound.
  • Temperature Effects: Solubility can be affected by temperature; thus, increasing the temperature might enhance its solubility in organic solvents.
  • pH Dependence: The solubility could also be influenced by the pH of the medium. Some ammonium compounds can dissociate or interact differently depending on the acidity or basicity of the environment.

In conclusion, while the solubility of this complex quinozaline derivative is limited in aqueous solutions, it may find greater compatibility in organic solvents. Understanding solubility properties is crucial for applications in pharmaceuticals and chemical synthesis, as it influences bioavailability and reaction kinetics.

Interesting facts

Interesting Facts about 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-diethyl-methyl-ammonium;iodide

This intriguing compound, often referred to for its multifaceted structure, represents a fascinating intersection of pharmaceutical chemistry and organic synthesis. Here are some notable points:

  • Pharmacological Potential: Compounds featuring the quinazoline moiety are often researched for their anti-cancer and anti-inflammatory properties. The presence of a sulfur atom in this compound may enhance its biological activity by improving interaction with biological targets.
  • Ammonium Ion: The presence of the quaternary ammonium ion structure plays a crucial role in increasing solubility and bioavailability, making it a valuable candidate for drug formulation.
  • Chloro Substituent: The 7-chloro group is instrumental in modulating the reactivity and pharmacokinetics of the compound, potentially improving its efficacy against specific targets.
  • Structural Complexity: With its sophisticated molecular architecture, this compound showcases the beauty of organic synthesis, highlighting how slight modifications can lead to significant changes in functionality.

This compound exemplifies the intricate balance between design and synthesis in chemistry, where researchers continually explore new derivatives and their possible applications in medicinal chemistry. As we state in the field, "The only limit to the possibilities of chemistry is our imagination."

Given time and research, there is immense potential for compounds like this to lead to innovative solutions in disease treatment and other field applications!

Synonyms
15589-19-2
Ammonium, (2-((3,4-dihydro-7-chloro-4-oxo-3-phenyl-2-quinazolinyl)thio)ethyl)diethylmethyl-, iodide
DTXSID20935305
2-[(7-Chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]-N,N-diethyl-N-methylethan-1-aminium iodide