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Notumetinib

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Identification
Molecular formula
C19H20ClN3O2
CAS number
7553-73-3
IUPAC name
2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium
State
State

This compound is in the solid state at room temperature.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
348.00
Boiling point (Kelvin)
621.15
General information
Molecular weight
391.92g/mol
Molar mass
391.9240g/mol
Density
1.2400g/cm3
Appearence

The compound appears as a solid. It is a crystalline substance, typically presenting as a light yellow powder.

Comment on solubility

Solubility of 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium

The solubility of 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium in various solvents can be influenced by a number of factors. Understanding these factors is essential for practical applications in pharmaceuticals and other fields. Here are a few considerations regarding its solubility:

  • Polarity: The presence of trimethyl ammonium groups may increase the overall polarity of the compound, suggesting that it could be more soluble in polar solvents, such as water and alcohols.
  • Hydrophobic Interactions: The phenyl ring in the structure may contribute to hydrophobic interactions, which can complicate solubility in aqueous environments.
  • Temperature Influence: Solubility is often temperature-dependent, and increasing temperature may enhance the solubility of this compound, making it important to consider during experiments.

Moreover, it is worth noting that "like dissolves like." Therefore, potential solubility in:

  • Polar solvents: water, methanol
  • Less polar solvents: DMSO, acetone

In conclusion, while the precise solubility characteristics of this specific compound are still to be investigated in detail, the combination of its structural features and external conditions creates a dynamic profile that is crucial for its utilization in various applications.

Interesting facts

Interesting Facts about 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium

This compound is a fascinating example of a nitrogen-containing heterocycle with interesting biological activity. Its structure features a quinazolinone ring which is known for its broad range of therapeutic properties. Below are some remarkable aspects of this compound:

  • Biological Significance: The quinazolinone core is often found in pharmaceuticals due to its potential as an antimicrobial, anti-inflammatory, and anticancer agent. Compounds with this structure can disrupt various biological pathways, making them of high interest in drug discovery.
  • Chlorinated Variants: The presence of a chloro substituent provides unique reactivity and may influence the compound's pharmacokinetic properties, such as absorption and metabolism.
  • Ammonium Group: The trimethylammonium moiety can significantly enhance solubility in biological systems, promoting the compound's uptake in cellular environments, which is crucial for its therapeutic efficacy.
  • Sulfanyl Group: The sulfanylethyl group may play a role in modulating interactions with biomolecules, offering interesting avenues for research into its function as a ligand or inhibitor in various biochemical assays.

In a research context, this compound stands at the intersection of organic chemistry and medicinal chemistry. As scientists explore its properties, they may unlock new methodologies or treatments for a variety of ailments. "Chemistry is not just a subject, it's a key to understanding the world around us," a quote that rings especially true for compounds like this one, where intricate design can lead to significant health benefits.

Continued investigation into 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium may offer valuable insights into the potential applications of quinazolinone derivatives in modern medicine.