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Pyrimethamine iodide

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Identification
Molecular formula
C21H23ClIN3OS
CAS number
74550-97-3
IUPAC name
2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium;iodide
State
State

At room temperature, pyrimethamine iodide is a solid. It is commonly available in its crystalline form, making it suitable for pharmaceutical applications as a solid substance.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
458.79g/mol
Molar mass
458.7920g/mol
Density
1.5842g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It is often odorless and can absorb moisture from the air, becoming more prone to degradation.

Comment on solubility

Solubility of 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium; iodide

The solubility of 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium; iodide can be influenced by various factors due to its complex molecular structure. Here are some key points to consider:

  • Polarity: The presence of the trimethyl ammonium group contributes to the overall polarity of the compound, which may enhance its solubility in polar solvents, like water.
  • Functional Groups: The iodide component can also increase the compound's solubility because halides tend to form soluble salts.
  • Temperature: As with many ionic compounds, higher temperatures may help improve solubility by facilitating interactions with the solvent.
  • pH Dependency: The solubility may change with pH, as protonation states of the nitrogen atoms in the ammonium group can vary in acidic or basic conditions.

In conclusion, while specific solubility data for this compound may not be readily available, it is reasonable to anticipate solubility in polar solvents due to its ionic nature and functional groups. This compound showcases the interplay between structure and solubility in the realm of chemical compounds.

Interesting facts

Interesting Facts about 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium iodide

This compound is a fascinating example of a quaternary ammonium salt, which plays a significant role in chemical synthesis and biological applications. Here are some noteworthy aspects:

  • Quaternary Ammonium Compounds: These compounds are known for their antibacterial and antifungal properties, making them valuable in medical and industrial fields. Their *cationic* nature allows them to interact well with negatively charged surfaces, such as cell membranes.
  • Pharmacological Potential: The structure of this compound indicates a potential for pharmacological activity, particularly due to the presence of the quinazoline ring. Quinazolines are a pivotal class of compounds in drug development, often exhibiting anti-cancer, anti-inflammatory, and anti-viral properties.
  • Synthesizing Challenges: The synthesis of this compound requires careful manipulation of various reagents and conditions, showcasing the intricate nature of creating compounds with specific biological functionalities. Chemists often need to monitor reaction conditions meticulously to ensure desired outcomes.
  • Research Importance: Research on compounds like this is ongoing, with scientists investigating how modifications to the molecular structure can enhance bioactivity and reduce toxicity. Studies often aim to optimize the balance between efficacy and safety.
  • Structural Diversity: The addition of different functional groups, such as the chlorinated phenyl and sulfonium components, not only expands the diversity of synthetic pathways but also allows for the exploration of multifaceted biological targets.

In conclusion, 2-(7-chloro-4-oxo-3-phenyl-quinazolin-2-yl)sulfanylethyl-trimethyl-ammonium iodide is more than just a chemical compound; it's a gateway into the world of medicinal chemistry, where nuances in molecular design can lead to groundbreaking therapies. As researchers continue to delve into the properties and potential uses of this unique compound, it stands as a reminder of the complexities and possibilities present within the realm of chemistry.

Synonyms
Ammonium, (2-((3,4-dihydro-7-chloro-4-oxo-3-phenyl-2-quinazolinyl)thio)ethyl)trimethyl-, iodide
15589-20-5
DTXSID80935306
2-[(7-Chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]-N,N,N-trimethylethan-1-aminium iodide