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Clonazepam

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Identification
Molecular formula
C16H13ClN5O3
CAS number
1622-61-3
IUPAC name
2-(8-methoxy-11-methyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium;chloride
State
State

At room temperature, clonazepam is in a solid state, appearing as a powder. It is stable under normal conditions and is typically formulated into tablets or capsules for medical use.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.15
General information
Molecular weight
353.79g/mol
Molar mass
353.7870g/mol
Density
1.3000g/cm3
Appearence

Clonazepam is a white to light yellow crystalline powder. Its appearance is characterized by its fine crystalline structure, which is typical for many pharmaceutical compounds.

Comment on solubility

Solubility of 2-(8-methoxy-11-methyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium;chloride

The solubility of 2-(8-methoxy-11-methyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium;chloride is of significant interest due to its complex structure. Several factors influence the solubility of this compound:

  • Polarity: The presence of the ammonium group suggests a higher polarity, potentially enhancing solubility in polar solvents such as water.
  • Interactions: The ability to form hydrogen bonds with water molecules may further aid in its dissolution. The methoxy group could also contribute to its interactions with organic solvents.
  • Temperature Dependence: Solubility can vary with temperature, and it is often observed that higher temperatures increase solubility for many salts.
  • Formulation: The presence of chloride ions indicates that this compound may exist as a salt, which typically increases solubility in aqueous solutions compared to its neutral form.

In practical applications, understanding the solubility behavior of such a compound is critical for its formulation in pharmaceuticals, as it influences bioavailability and efficacy. Solubility can also be assessed using methods like:

  1. Quantitative analysis using high-performance liquid chromatography (HPLC).
  2. Qualitative assessments via solubility tests in various organic solvents.

To summarize, solubility plays a pivotal role in the application of 2-(8-methoxy-11-methyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium;chloride, making it essential for scientists and formulators to examine its behavior in multiple environments.

Interesting facts

Interesting Facts about 2-(8-methoxy-11-methyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium;chloride

This unique compound, belonging to the benzodiazepine family, showcases an intriguing combination of psychoactive and therapeutic properties. Benzodiazepines are renowned for their ability to modulate the neurotransmitter system, primarily acting as anxiolytics and sedatives.

Properties and Applications

  • Neuropharmacology: This compound operates primarily by influencing the gamma-aminobutyric acid (GABA) receptors in the brain, which can lead to a calming effect on the nervous system.
  • Therapeutic Uses: It has potential applications in treating anxiety disorders, insomnia, and muscle spasms, providing relief for various conditions stemming from excessive neuronal excitability.
  • Chemical Complexity: The presence of the methoxy and dimethylammonium groups contributes to its unique biological activity, enhancing its lipophilicity and potentially improving its pharmacokinetic properties.

Historical Insight

The study of benzodiazepines began in the 1950s, with their introduction revolutionizing psychopharmacology. Their discovery marked a turning point in the treatment of mental health disorders, leading to a widespread reassessment of therapeutic strategies.

Current Research

Research is ongoing into the effects of this compound and similar derivatives. Scientists are exploring:

  • Novel formulations: These studies aim to improve efficacy and reduce side effects.
  • Alternative applications: Investigating potential uses beyond anxiolytic effects, such as neuroprotection and anti-inflammatory properties.

As a chemistry student or a seasoned scientist, understanding the nuances of compounds like this can provide powerful insights into both the challenges and breakthroughs in pharmaceuticals. The combination of structure and function within such complex molecules is a testament to the intricate relationship between chemistry and biology.

Synonyms
1668-73-1
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-10-(2-(dimethylamino)ethyl)-2-methoxy-5-methyl-, hydrochloride