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N-Desmethylclozapine hydrochloride

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Identification
Molecular formula
C18H25ClN2O2
CAS number
23132-02-5
IUPAC name
2-(8-methyl-1,4-dioxaspiro[4.5]decan-3-yl)piperidin-1-ium;chloride
State
State

At room temperature, N-Desmethylclozapine hydrochloride is in a solid state, typically as a powder.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
342.87g/mol
Molar mass
342.8650g/mol
Density
1.1500g/cm3
Appearence

N-Desmethylclozapine hydrochloride typically appears as a crystalline powder that is white to off-white in color.

Comment on solubility

Solubility of 2-(8-methyl-1,4-dioxaspiro[4.5]decan-3-yl)piperidin-1-ium;chloride

The solubility of 2-(8-methyl-1,4-dioxaspiro[4.5]decan-3-yl)piperidin-1-ium chloride can be complex and is influenced by several factors. Here are some key points to consider:

  • Polarity: The presence of the piperidin-1-ium moiety indicates that this compound is likely polar, which usually enhances its solubility in polar solvents like water.
  • Piperidinium Ion: The piperidinium ion is known for increasing water solubility due to its ionic nature. Thus, one can predict that the chloride salt form would further promote solubility in aqueous environments.
  • Hydrogen Bonding: The existence of dioxaspiro structures may allow for hydrogen bonding, which can stabilize the compound in solution and enhance solubility.
  • Solvent Choice: Solubility can significantly vary based on the choice of solvent. This compound is expected to have limited solubility in non-polar solvents.

In conclusion, while the overall solubility of 2-(8-methyl-1,4-dioxaspiro[4.5]decan-3-yl)piperidin-1-ium;chloride seems promising in polar solvents due to its structure, empirical data would be necessary to provide specific solubility values.

Interesting facts

Exploring 2-(8-methyl-1,4-dioxaspiro[4.5]decan-3-yl)piperidin-1-ium;chloride

This intriguing compound, often recognized by its complex structure and rich functionality, belongs to a class of compounds known for their multiple applications in various fields. Let's delve deeper into some fascinating aspects:

  • Complex Structure: The compound features a spirocyclic framework, highlighted by the presence of a dioxaspiro moiety. This unique architecture contributes to its distinctive chemical properties and potential interactions.
  • Ionizable Nature: The piperidin-1-ium part of the molecule indicates that it is a quaternary ammonium ion. As a result, it showcases interesting ionic characteristics that make it useful in various chemical reactions.
  • Potential Biological Activity: Compounds with piperidine derivatives are often investigated for their biological activities. The presence of the dioxaspiro configuration can enhance the compound's pharmacological profile, making it a candidate for further research in medicinal chemistry.
  • Wave of Interest: Chemists are increasingly focused on spiro compounds due to their unique arrangements, which can lead to *originally unexplored synthesis pathways* and novel properties.
  • Synthetic Versatility: The intricate structure of this compound allows for several synthetic routes, promoting *challenges and opportunities* in organic synthesis practices among chemists.

In summary, 2-(8-methyl-1,4-dioxaspiro[4.5]decan-3-yl)piperidin-1-ium;chloride represents a fascinating intersection of structural complexity, potential biological relevance, and synthetic capability. As research continues, this compound could unveil new horizons in both organic chemistry and pharmaceutical developments.

Synonyms
8-Methyl-2-(2-piperidyl)-1,4-dioxaspiro(4.5)decane hydrochloride
1,4-DIOXASPIRO(4.5)DECANE, 8-METHYL-2-(2-PIPERIDYL)-, HYDROCHLORIDE
7538-26-3