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Fluticasone Propionate

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Identification
Molecular formula
C22H27F2O4S
CAS number
80474-14-2
IUPAC name
[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate
State
State

At room temperature, fluticasone propionate is typically in a solid state.

Melting point (Celsius)
273.00
Melting point (Kelvin)
546.15
Boiling point (Celsius)
512.00
Boiling point (Kelvin)
785.15
General information
Molecular weight
500.56g/mol
Molar mass
500.5630g/mol
Density
1.4900g/cm3
Appearence

Fluticasone propionate appears as a white to off-white powder. It may have a slightly characteristic odor and is practically insoluble in water.

Comment on solubility

Solubility of 2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate

The solubility of the compound 2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate can be analyzed based on its structural characteristics:

  • Hydrophilic and Hydrophobic Regions: The presence of dihydrogen phosphate groups typically increases solubility in water due to their ability to form hydrogen bonds.
  • Alkyl Chain Influence: The significant hydrophobic portions of the molecule may reduce overall solubility in polar solvents.
  • pH Dependence: As a phosphate derivative, the solubility may further be influenced by the pH of the solution, which can lead to protonation or deprotonation of functional groups.

In general, compounds containing both hydrophilic and hydrophobic features tend to display variable solubility based on environmental factors. As an illustrative quote might state, "The structure of a molecule determines its solubility, the balance of polar and non-polar attributes being the key." Overall, one could anticipate that this compound may exhibit moderate solubility in aqueous solutions while remaining less soluble in non-polar solvents.

Interesting facts

Interesting Facts about 2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate

This compound is a unique phosphoric acid derivative that plays a significant role in biochemical processes. Here are some fascinating insights that highlight its significance:

  • Biological Activity: Compounds similar to this one often exhibit interesting biological activities, which can include antitumor properties or the regulation of various enzymes, making them subjects of pharmaceutical interest.
  • Structural Complexity: The molecular structure of this compound features a complex arrangement of rings and functional groups, which provides a unique scaffold for potential interactions with biological macromolecules.
  • Fluorine Substitution: The presence of a fluorine atom in its structure can significantly enhance the compound's pharmacological properties. Fluorinated compounds are often more biologically active due to their stability and ability to interact favorably with biological targets.
  • Phosphate Group: The dihydrogen phosphate moiety is crucial for the compound's interaction with biological systems, as phosphate groups are vital in energy transfer reactions, often seen in ATP and DNA structures.
  • Applications in Medicine: Compounds of this nature are being explored for their potential therapeutic applications. They may serve as leads for drug development in fields such as oncology and endocrinology.

In summary, the intricate structure and potential biological activities of this compound make it a noteworthy subject for further research and exploration in the field of medicinal chemistry. As scientists continue to unravel the complexities of such molecules, we move closer to understanding their full capabilities and applications in medicine.

Synonyms
dexamethasone phosphate
312-93-6
Dexamethasone 21-phosphate
Betnelan phosphate
Hexadrol phosphate
Neodecadron
Wymesone
Oradexon phosphate
Dexamethasone 21-orthophosphate
Dexamethasone-21-dihydrogen-phosphate
Dexamethasone-21-phosphate
EGP-437
EINECS 206-232-0
2BP70L44PR
CHEBI:68637
Decadron-phosphate (TN)
DTXSID2047430
312-93-6 (acid)
DEXAMETHASONE PHOSPHATE [VANDF]
(11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
AL38905
DEXAMETHASONE PHOSPHATE [MART.]
DEXAMETHASONE PHOSPHATE [USP-RS]
DEXAMETHASONE PHOSPHATE [WHO-DD]
DEXAMETHASONE DIHYDROGEN PHOSPHATE
AL-38905
[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate
9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-(dihydrogen phosphate)
DEXAMETHASONE PHOSPHATE (MART.)
DEXAMETHASONE PHOSPHATE (USP-RS)
(11alpha,16alpha)-9-Fluoro-11,17-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl Dihydrogen Phosphate
2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl dihydrogen phosphate
9-FLUORO-11.BETA.,17,21-TRIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-(DIHYDROGEN PHOSPHATE)
PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11,17-DIHYDROXY-16-METHYL-21-(PHOSPHONOOXY)-,(11.BETA.,16.ALPHA.)-
Dexamethasone 21-(dihydrogen phosphate)
erydex
UNII-2BP70L44PR
Decadron-phosphate
DEXAMETHASONE PHOSPHORIC ACID
SCHEMBL135283
CHEMBL1201302
DTXCID5031345
HY-B1829
AKOS016007098
DA-52469
CS-0013898
D07802
Q27137065
(11alpha,16beta)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
206-232-0
3T5
PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11,17-DIHYDROXY-16-METHYL-21-(PHOSPHONOOXY)-,(11BETA,16ALPHA)-