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Dexamethasone phosphate

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Identification
Molecular formula
C22H30FO8P
CAS number
55203-24-2
IUPAC name
[2-[(8S,9R,10S,11S,13S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate
State
State

At room temperature, dexamethasone phosphate is in a solid state. It is often handled and stored as a dry powder to ensure stability and prevent hygroscopic degradation.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
289.90
Boiling point (Kelvin)
563.05
General information
Molecular weight
472.42g/mol
Molar mass
472.4190g/mol
Density
1.4700g/cm3
Appearence

Dexamethasone phosphate appears as a white to off-white crystalline powder. It is practically odorless and hygroscopic, meaning it absorbs moisture from the air. The compound is often used in its pure form in research and pharmaceutical applications.

Comment on solubility

Solubility of 2-[(8S,9R,10S,11S,13S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate

The solubility of the compound known as 2-[(8S,9R,10S,11S,13S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate is an intriguing topic for discussion, primarily due to its complex structure. Below are some important points regarding its solubility characteristics:

  • Solvent Interaction: The presence of phosphoric acid groups within the molecule suggests potential interactions with polar solvents, which could enhance solubility in water or aqueous systems.
  • Hydrophobic Regions: Conversely, the hydrophobic nature of the octahydrocyclopenta[a]phenanthrene structure could impede solubility in water but may facilitate dissolution in organic solvents.
  • pH Dependence: The solubility may also vary with pH, as protonated and deprotonated forms could affect how this compound interacts with solvent molecules.
  • Concentration Effects: At higher concentrations, solubility may be limited due to tendency to aggregate or precipitate.

In essence, understanding the solubility of this compound requires careful consideration of its molecular characteristics, potential solvent interactions, and environmental conditions. As a result, experimental determination of solubility is essential for practical applications in various fields, including pharmaceutical development and chemical synthesis.

Interesting facts

Interesting Facts about 2-[(8S,9R,10S,11S,13S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] Dihydrogen Phosphate

This complex compound, commonly recognized in the field of biochemistry and medicinal chemistry, has garnered significant attention due to its multifaceted roles in various biochemical processes. Here are some compelling aspects worth exploring:

  • Pharmacological Significance: The presence of fluoride and hydroxyl groups lends this compound unique properties, making it a potential candidate for therapeutic applications, particularly in hormone regulation and cancer therapy.
  • Stereochemistry: With multiple chiral centers, the compound's stereochemistry plays a crucial role in determining its biological activity. The specific configuration of its stereocenters can influence how it interacts with biological targets, underscoring the importance of stereochemistry in drug design.
  • Structural Complexity: Its intricate structure, characterized by a cyclopenta[a]phenanthrene backbone, not only provides stability but may also facilitate interactions with lipid membranes, enhancing its bioavailability.
  • Phosphate Group Role: The dihydrogen phosphate group is vital in biochemical signaling pathways, often acting as a crucial link in phosphorylation processes that regulate numerous cellular functions.

As a chemical scientist, it is fascinating to consider how compounds such as this can lead to breakthroughs in our understanding of complex biological systems. Research into its properties and mechanisms can pave the way for the development of innovative therapeutic agents. As the saying goes, "The more we know, the better we can innovate." Understanding the nuances of such compounds is crucial in the ongoing pursuit of effective treatments in modern medicine.

Synonyms
PDSP2_001630