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Dexamethasone phosphate

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Identification
Molecular formula
C22H29FO5P
CAS number
2392-39-4
IUPAC name
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2-(diethylamino)acetate;hydrochloride
State
State

At room temperature, dexamethasone phosphate is typically found as a solid powder.

Melting point (Celsius)
241.00
Melting point (Kelvin)
514.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
516.40g/mol
Molar mass
516.4040g/mol
Density
1.4200g/cm3
Appearence

Dexamethasone phosphate appears as a white to off-white crystalline powder. It is odorless and is soluble in water and alcohol, moderately soluble in methanol, and practically insoluble in chloroform and ether.

Comment on solubility

Solubility of the Compound

The solubility of 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2-(diethylamino)acetate; hydrochloride can be influenced by a number of factors, reflecting its complex structure. Understanding its solubility is crucial for applications in pharmaceuticals and other fields. Here are some key points to consider:

  • Hydrochloride Form: The presence of a hydrochloride group often enhances the solubility in polar solvents, especially water.
  • Amine Group: The diethylamino component suggests potential solubility in aqueous solutions due to the basic nature of the amine, which can interact favorably with water.
  • Hydrophobic Regions: The hydrocarbon backbone, characterized by multiple rings and alkyl groups, may impart a degree of hydrophobicity, potentially reducing solubility in water.
  • pH Sensitivity: The solubility might be pH-dependent; changes in pH could affect the ionization state of the diethylamino group, altering how the compound interacts with solvents.

Overall, while the compound may exhibit reasonable solubility in polar solvents due to the ionic nature of its hydrochloride form and the basic amine moiety, it is essential to conduct empirical solubility tests under varying conditions to fully understand its behavior. As noted, “the structure dictates the properties,” and in this case, the intricate arrangement of functional groups will ultimately influence solubility outcomes.

Interesting facts

Interesting Facts about 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2-(diethylamino)acetate; hydrochloride

This compound, with its complex structure, is part of a class of molecules known for their notable pharmacological properties. Scientists and researchers have taken a keen interest in compounds like this due to their potential therapeutic applications. Here are some fascinating insights:

  • Structural Complexity: Its intricate arrangement features multiple chiral centers, emphasizing the importance of stereochemistry in drug design.
  • Pharmacological Potential: Compounds with similar structures have been studied extensively for their ability to interact with various biological targets, which may lead to advancements in treating chronic conditions.
  • Natural Occurrence: Many compounds within this category are derived from natural products, often showcasing how nature's own designs can inspire synthetic chemistry.
  • Research Frontiers: Ongoing studies continue to explore its mechanism of action and efficacy, highlighting the dynamic nature of chemical research.
  • Therapeutic Implications: The potential applications in fields such as oncology or cardiology are being investigated, indicating a bright future for compounds like this.

"Every compound tells a story, and understanding that narrative can unlock new paths in medicine."

Research on such compounds contributes significantly to our understanding of molecular interactions and their implications in health and disease, thereby paving the way for innovative treatments. As we delve deeper into the chemistry behind this fascinating molecule, the possibilities seem limitless!

Synonyms
HYDROCORTAMATE HYDROCHLORIDE
Magnacort
125-03-1
Ulcort
Hydrocortamate HCl
UNII-9QM8U7R83W
Hydrocortisone 21-(diethylamino)acetate hydrochloride
EINECS 204-723-4
NSC-12884
9QM8U7R83W
17-hydroxycorticosterone 21-(diethylamino)acetate hydrochloride
CHEBI:50854
NSC 12884
11beta,17alpha,21-Trihydroxypregn-4-ene-3,20-dione 21-diethylaminoacetate hydrochloride
Cortisol, 21-ester with N,N-diethylglycine, hydrochloride
Glycine, N,N-diethyl-, 21-ester with cortisol, hydrochloride
Glycine, N,N-diethyl-, (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester, hydrochloride
HYDROCORTAMATE HYDROCHLORIDE (MART.)
HYDROCORTAMATE HYDROCHLORIDE [MART.]
RefChem:58049
204-723-4
11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl N,N-diethylglycinate hydrochloride
Ethamicort
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2-(diethylamino)acetate;hydrochloride
Magnacort; NSC 12884; Ulcort; Ethamicort
Hydrocortamate chloride
orb1696978
SCHEMBL1237011
CHEMBL1200635
AKQNAIYKSALPKV-OYHXESGYSA-N
DTXSID301027630
NSC12884
AKOS040752047
Cortisol,N-diethylglycine, hydrochloride
HYDROCORTAMATE HYDROCHLORIDE [MI]
HYDROCORTAMATE HYDROCHLORIDE [WHO-DD]
NS00079172
HYDROCORTAMATE HYDROCHLORIDE [ORANGE BOOK]
Hydrocortisone 21-diethylaminoacetate hydrochloride
Q27122238
17-Hydroxycorticosterone 21-diethylaminoacetate hydrochloride
11.BETA.,17.ALPHA.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 21-DIETHYLAMINOACETATE HYDROCHLORIDE
Glycine,N-diethyl-, (11.beta.)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester, hydrochloride