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Betamethasone acetate

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Identification
Molecular formula
C24H31FO6
CAS number
987-24-6
IUPAC name
[2-[(8S,9S,10R,11S,13S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2-(diethylamino)acetate
State
State

At room temperature, betamethasone acetate is in a solid state as a crystalline powder.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
466.51g/mol
Molar mass
466.5270g/mol
Density
1.0600g/cm3
Appearence

Betamethasone acetate appears as a white to creamy white crystalline powder. It is odorless or may have a slight, characteristic odor. The compound is stable under normal conditions but should be protected from light to prevent degradation.

Comment on solubility

Solubility of 2-[(8S,9S,10R,11S,13S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2-(diethylamino)acetate

The solubility of a compound often plays a crucial role in its application and function, especially in pharmaceutical and biochemical contexts. This particular compound, known for its complex structure, exhibits unique solubility characteristics influenced by several factors.

Factors Affecting Solubility

  • Polar vs. Nonpolar Nature: The presence of polar functional groups, such as hydroxyl (-OH) and amino (-NH) groups, can significantly increase solubility in polar solvents like water.
  • Molecular Structure: The intricate cyclic structures and molecular weight may lead to low solubility compared to smaller, simpler compounds.
  • Interactions with Solvent: Solubility may also depend on how well the compound interacts with the solvent molecules, governed by hydrogen bonding and van der Waals forces.
  • Temperature: Typically, increasing temperature can enhance solubility due to increased molecular motion, although exceptions exist.

While the precise solubility data for this compound may not be readily available, it can be inferred that it may demonstrate limited solubility in aqueous solutions due to its complex structure. Compounds like these often show better solubility in organic solvents such as acetone or chloroform. As stated, "Like dissolves like," meaning this compound may find better solvation in nonpolar or moderately polar environments compared to highly polar solvents.

In conclusion, understanding the solubility of 2-[(8S,9S,10R,11S,13S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2-(diethylamino)acetate entails considering both its molecular features and the context of its use, providing essential insight for practical applications.

Interesting facts

Exploring 2-[(8S,9S,10R,11S,13S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2-(diethylamino)acetate

The compound we are examining is a fascinating example of complex organic chemistry, specifically falling into the category of steroids and their derivatives. The intricate structure and functional groups present in this molecule offer a myriad of potential applications in various fields. Here are some interesting insights:

  • Biological Significance: This compound could mimic or inhibit natural steroids due to its structural similarity, leading to significant implications in pharmacology and medicinal chemistry.
  • Synthetic Pathways: The synthesis of such complex compounds often requires advanced techniques such as multi-step organic synthesis, making it a popular subject of study among organic chemists.
  • Potential Therapeutic Uses: The presence of hydroxyl groups suggests possible interactions with biological receptors, which could lead to new potential therapies for hormonal disorders or other diseases.
  • Structure-Activity Relationship (SAR): Understanding how the specific stereochemistry (as indicated by the S and R designations) impacts biological activity can yield insights for drug design and development.

As chemists continue to explore the properties and reactions of such compounds, it's essential to consider their role not just in synthetic chemistry, but also in the wider context of biochemistry and pharmacology. The complexity of the structure, with multiple functional groups and stereocenters, emphasizes the beauty of organic compounds and the intricacies involved in their function and application. Each additional hydroxyl or alkyl substitution can drastically change the compound's reactivity and affinity, making it a rich area for exploration and study.