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Dexamethasone phosphate

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Identification
Molecular formula
C22H30FO8P
CAS number
2392-39-4
IUPAC name
[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] phosphate
State
State

At room temperature, dexamethasone phosphate is typically in a solid state, appearing as a powder.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.00
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.00
General information
Molecular weight
516.45g/mol
Molar mass
516.4200g/mol
Density
1.5000g/cm3
Appearence

Dexamethasone phosphate typically appears as a white to off-white crystalline powder. It is often used in its hydrated form, and the crystals can seem slightly translucent depending on the hydration level.

Comment on solubility

Solubility of [2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] phosphate

The solubility of the compound with the formula C22H30FO8P can be described as follows:

  • General Solubility: This compound is expected to have moderate solubility in organic solvents due to the presence of hydrophobic regions within its structure.
  • Hydrophilic and Hydrophobic Balance: The phosphate group contributes to hydrophilicity, while the bulky cyclic structure and fluorine substitution impart hydrophobic characteristics. This balance may influence its solubility behavior in polar and non-polar solvents.
  • Solvent Effects: Common solvents such as ethanol or dimethyl sulfoxide (DMSO) may enhance solubility compared to water, where ionic compounds often exhibit low solubility.
  • pH Dependency: The solubility can be influenced by the pH of the solution; the phosphate group may ionize, especially in basic conditions, increasing the solubility in those environments.

In summary, while the compound exhibits moderate solubility characteristics, various factors, including solvent choice, pH, and the structural features of the compound itself, play critical roles in determining its solubility. As noted, this intricate balance creates a fascinating area of study in solubility chemistry.

Interesting facts

Interesting Facts about 2-(9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl phosphate

This compound is a fascinating member of the steroid family, exhibiting both biological and chemical significance. Steroids have long been recognized for their pivotal roles in physiology, particularly in the field of endocrinology. Here are some interesting insights:

  • Pharmaceutical Importance: This compound may have therapeutic applications that mirror those of other steroids, making it a point of interest in drug development for treating various hormonal imbalances.
  • Structural Complexity: The intricate structure of this compound, featuring multiple functional groups and a unique ring system, showcases the beauty of organic chemistry and highlights the challenges involved in synthesizing such molecules.
  • Fluorine Atom: The presence of a fluorine substituent could potentially enhance the biological activity of the molecule due to its electronegativity, which can influence interactions with biological targets.
  • Phosphate Group: The phosphate moiety plays a crucial role, often associated with increased solubility and bioavailability, which is particularly valuable in medicinal chemistry.
  • Research Potential: Continuous study of this compound may lead to enhanced understanding of its mechanisms of action, paving the way for new therapeutic strategies.

In summary, this compound embodies a captivating intersection of chemistry and biology, making it a powerful subject for ongoing research. Its structural and functional characteristics offer a plethora of opportunities for future explorations in both pharmaceuticals and biochemical understanding.

Synonyms
NSC803074
NSC-803074