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Fluticasone propionate

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Identification
Molecular formula
C25H31F1O5
CAS number
80474-14-2
IUPAC name
[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 3,3-dimethylbutanoate
State
State

Fluticasone propionate is a solid at room temperature. It is typically processed into a powder form for use in pharmaceutical applications, particularly in inhalers and creams.

Melting point (Celsius)
273.00
Melting point (Kelvin)
546.15
Boiling point (Celsius)
336.00
Boiling point (Kelvin)
609.15
General information
Molecular weight
500.57g/mol
Molar mass
500.5730g/mol
Density
1.2200g/cm3
Appearence

Fluticasone propionate typically appears as a white powder. It is odorless and is commonly available in micronized form for use in various pharmaceutical formulations. The powder is often used in inhalers or topical creams.

Comment on solubility

Solubility of [2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 3,3-dimethylbutanoate

The solubility of the compound [2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 3,3-dimethylbutanoate is influenced by several factors due to its complex structure. Understanding the solubility characteristics can guide its applications in various fields.

Factors Affecting Solubility

  • Molecular Structure: The presence of the 9-fluoro and multiple hydroxyl groups significantly affects hydrogen bonding, which enhances solubility in polar solvents.
  • Hydrophobic and Hydrophilic Balance: The compound exhibits both hydrophobic (due to its aromatic and saturated hydrocarbon regions) and hydrophilic (due to the hydroxyl and carbonyl groups) characteristics.
  • Solvent Interaction: Solubility will vary considerably in different solvents, being likely more soluble in organic solvents like ethanol and dimethyl sulfoxide compared to water.

Quote: "Like dissolves like." This classic chemistry maxim highlights the tendency of solvents to dissolve solutes of similar polarity. Therefore, polar solvents may dissolve the hydrophilic parts more effectively, while non-polar solvents might favor solubility of the hydrophobic regions.

General Solubility Insights

  • Expected to be more soluble in organic solvents than in water.
  • Solubility may increase with temperature, common for many organic compounds.

Overall, the solubility of this compound represents a balance between its functional groups and molecular geometry, making it a fascinating subject for further exploration in chemical and pharmaceutical applications.

Interesting facts

Interesting Facts about [2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 3,3-dimethylbutanoate

This compound presents a fascinating example of complexity in molecular architecture, showcasing multiple functional groups and a unique stereochemical arrangement. Here are some compelling insights about it:

  • Biological Relevance: Compounds with similar structures often exhibit significant biological activities, particularly in the pharmaceutical realm.
  • Drug Development: The intricacy of this molecule suggests potential utility in drug design, especially for targeting specific receptors in the body.
  • Structural Diversity: This compound features a combination of steroid and non-steroid elements, making it a unique candidate for studies in structure-activity relationships.
  • Fluorination: The presence of a fluorine atom is notable, as fluorinated compounds frequently exhibit enhanced metabolic stability and bioactivity.

As a scientist or chemistry student, one might find it enthralling to consider the implications of such complex molecular structures:

  1. Molecular Design: Understanding the synthesis and reactivity of such a compound could lead to insights into the creation of more effective drugs.
  2. Research Opportunities: The diverse functional groups suggest numerous pathways for modification, encouraging explorations in organic synthesis.
  3. Educational Value: Studying this compound allows for a rich discussion on the principles of chirality, stereochemistry, and the interplay between structure and function.

Overall, the study of [2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 3,3-dimethylbutanoate not only highlights the elegance of chemical complexity but also invites further inquiry into its practical applications and implications in modern chemistry.

Synonyms
DTXSID90947612
9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl 3,3-dimethylbutanoate
1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE 21-T-BUTYLACETATE