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Fmoc-Val-OH

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Identification
Molecular formula
C22H23NO4
CAS number
68858-19-1
IUPAC name
2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid
State
State

At room temperature, Fmoc-Val-OH is in a solid state. This compound is stable under ordinary conditions and commonly stored at low temperature to prevent degradation.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
322.50
Boiling point (Kelvin)
595.65
General information
Molecular weight
373.44g/mol
Molar mass
311.3620g/mol
Density
1.2890g/cm3
Appearence

Fmoc-Val-OH, known as Fluorenylmethyloxycarbonyl-valine, typically appears as a white to off-white crystalline powder. It is widely used as a building block in peptide synthesis, providing stability and ease of removal after the synthesis process.

Comment on solubility

Solubility of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid

The solubility of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid (C22H23NO4), also known as a complex amino acid derivative, can be influenced by several factors. Understanding these factors is essential for its practical applications in pharmaceuticals and organic synthesis. Here are some key points regarding its solubility characteristics:

  • Polarity: The presence of both hydrophilic (amino acid) and hydrophobic (fluorenyl) groups in the structure typically results in a moderate polarity, which can affect its solubility in various solvents.
  • Solvents: This compound may demonstrate better solubility in polar organic solvents, such as dimethyl sulfoxide (DMSO) and methanol, rather than in non-polar solvents like hexane.
  • pH Dependency: The solubility can significantly change with pH. As an acid, it may become more soluble in alkaline conditions due to deprotonation, which enhances its interaction with water molecules.
  • Concentration Effects: At different concentrations, aggregation or solubilization phenomena can occur, possibly leading to saturation limits that dictate practical solubility in solution.

In summary, the solubility of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid is multifaceted, influenced by its structural attributes, interaction with various solvents, and environmental conditions. Furthermore, practical experiments are always essential to confirm theoretical solubility predictions as the real-world behavior can deviate from expectations.

Interesting facts

Interesting Facts about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid

This compound, often referred to as a protecting group in organic synthesis, plays a crucial role in peptide synthesis and other complex organic transformations. Its structure features a fluorene moiety, which contributes to its stability and functionality. Here are some engaging aspects of this compound:

  • Protective Functionality: The 9H-fluoren-9-ylmethoxycarbonyl (Fmoc) group is widely used in solid-phase peptide synthesis. It offers a way to protect amino groups, allowing for selective reactions.
  • Versatile Applications: This compound is not only important in peptide synthesis but also in the design of novel pharmaceuticals and bioactive molecules.
  • Enhanced Stability: The fluorene structure contributes to the compound's photophysical properties, making it highly stable under various conditions, which is essential for laboratory manipulations.
  • Derivative Potential: By modifying the side groups, chemists can create a variety of derivatives, expanding the utility of this compound in scientific research.
  • Interaction with Biological Systems: Its structure can influence interactions with biological molecules, making it a point of interest for biochemical studies.

In the words of a renowned chemist, “The beauty of organic synthesis lies in the ability to construct complex molecules through strategic planning and the use of protecting groups.” This compound exemplifies that beauty, enabling chemists to achieve intricate molecular architectures!


Whether you are a linear thinker or a creative problem solver, the multifunctionality of this compound opens up an exciting realm of possibilities in organic chemistry!

Synonyms
DL-LEUCINE-D10-N-FMOC
126727-03-5
Fmoc-DL-leucine
2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
CHEMBL294989
N-Fmoc-D-leucine
NPC-15199
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid
2-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)-4-METHYLPENTANOIC ACID
NSC334290
L-Leucine-15N, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid
GTPL2705
SCHEMBL1002861
CHEBI:91726
FLL-1725-PI
DTXSID00860520
HMS3266H19
538372-74-6
BFA72703
BDBM50034787
AKOS001044199
AKOS017268980
AB01604
AB02467
NCGC00095919-01
NCGC00095919-02
SY035103
SY036884
DB-041215
(((9H-Fluoren-9-yl)methoxy)carbonyl)leucine
EN300-17201
AB01273269-03
N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}leucine
BRD-A47633927-001-01-8
Q27077695
Z56899084
2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-methylpentanoic acid
N- (9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE (NPC-15199)
2-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)-4-METHYLPENTANOICACID
N-(9-Fluorenylmethoxycarbonyl)-L-leucine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid