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Fluocinolone acetonide acetate

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Identification
Molecular formula
C24H30F2O6
CAS number
1119-34-2
IUPAC name
[2-[(9R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, fluocinolone acetonide acetate is a solid. It is stable under normal conditions but should be stored away from moisture and light to prevent degradation.

Melting point (Celsius)
253.00
Melting point (Kelvin)
526.15
Boiling point (Celsius)
540.00
Boiling point (Kelvin)
813.15
General information
Molecular weight
452.52g/mol
Molar mass
452.5150g/mol
Density
1.3000g/cm3
Appearence

Fluocinolone acetonide acetate typically appears as a white to off-white crystalline powder. It is insoluble in water and may have a faint odor. Its crystalline form allows it to be processed into various formulations for pharmaceutical use.

Comment on solubility

Solubility of 2-[(9R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate (C24H30F2O6)

The solubility of 2-[(9R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate is influenced by various factors. Understanding its solubility profile is essential for applications in pharmaceuticals and chemical industries. Here are some key points to consider:

  • Polarity: The presence of multiple hydroxyl (–OH) and acetate (–OCOCH3) functional groups suggests that this compound is likely to be polar. Such polarity often enhances solubility in polar solvents like water.
  • Hydrophobic Interactions: The large hydrocarbon framework of the compound can lead to hydrophobic interactions, which may reduce its solubility in polar solvents compared to non-polar solvents.
  • Temperature Dependence: Like many organic compounds, the solubility of this acetate derivative may increase with temperature, allowing for better dissolution in organic solvents.
  • Solvent Compatibility: This compound may exhibit notable solubility in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO) due to its larger non-polar regions.

In conclusion, the solubility of 2-[(9R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate can be characterized as varying between polar and non-polar solvents, and one should consider the balance of its functional groups while determining its behavior in different environments. As the famous saying goes, "Like dissolves like," and this encapsulates the essential principle of solubility for such complex compounds.

Interesting facts

Interesting Facts about 2-[(9R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate

This compound, with its complex structure, is a fascinating example of a synthetic derivative used in medicinal chemistry. It has garnered attention for its potential use in treating various ailments due to its unique biochemical properties. Here are a few notable facts:

  • Synthetic Origins: This compound belongs to a class of molecules that are synthesized to mimic natural hormones, particularly corticosteroids, which are crucial for numerous physiological processes.
  • Fluorination: The presence of a fluorine atom in its structure significantly alters the compound’s pharmacokinetic properties, enhancing its biological activity and stability compared to non-fluorinated versions.
  • Hydroxyl Groups: The two hydroxyl (–OH) groups in its structure contribute to its ability to interact with biological systems, functioning as key sites for hydrogen bonding, which can enhance binding affinity to target molecules.
  • Potential Applications: Research has indicated that analogs related to this compound may have applications in anti-inflammatory therapies and other conditions where modulation of glucocorticoid activity is beneficial.
  • Cyclopenta[a]phenanthrene Core: The intricate bicyclic framework not only offers structural stability but also serves as a template for further modifications to improve therapeutic efficacy.

In the words of renowned chemist Linus Pauling, "the best way to have a good idea is to have a lot of ideas." This compound embodies that philosophy in its multifaceted design, showcasing the beauty of organic synthesis and its relevance in pharmaceuticals.

As research into compounds of this nature continues, their potential implications in the realm of healthcare could be significant, paving the way for novel treatments rooted in the intricate dance of molecular interactions.

Synonyms
[2-[(9R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
AKOS024319500