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Fluocinolone acetonide acetate

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Identification
Molecular formula
C26H33FO6
CAS number
.null
IUPAC name
[2-[(9R,11S)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, Fluocinolone acetonide acetate is typically a solid, usually handled as a crystalline powder.

Melting point (Celsius)
274.00
Melting point (Kelvin)
547.20
Boiling point (Celsius)
590.40
Boiling point (Kelvin)
863.60
General information
Molecular weight
494.52g/mol
Molar mass
494.5150g/mol
Density
1.2244g/cm3
Appearence

Fluocinolone acetonide acetate appears as a white to off-white crystalline powder. It is odorless and stable under normal conditions of use and storage.

Comment on solubility

Solubility of 2-[(9R,11S)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate

The solubility of this complex organofluorine compound is influenced by several factors, given its intricate structure. Understanding its solubility provides insight into its potential applications and behavior in various environments.

Key Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl groups (–OH) makes the compound more polar, which generally increases its solubility in polar solvents, such as water.
  • Molecular Weight: With a relatively high molecular weight, the compound may exhibit lower solubility in water compared to smaller molecules, which can impede interaction with solvent molecules.
  • Hydrophobic Regions: The existence of hydrophobic carbon rings may lead to decreased solubility in polar solvents, necessitating the use of organic solvents like ethanol or dimethyl sulfoxide (DMSO).
  • Functional Groups: The ester and ketone functionalities in the structure can participate in hydrogen bonding, potentially enhancing solubility in specific conditions.

In summary, while the combined effects of polarity, hydrophobic and hydrophilic regions, and molecular weight play crucial roles in determining solubility, the unique structure of this compound suggests that it may be more soluble in organic solvents than in aqueous environments. It is essential to conduct empirical solubility testing to ascertain the exact behavior of this compound in various solvents.

Interesting facts

Interesting Facts about 2-[(9R,11S)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate

This compound, a derivative of the notable steroid structure, showcases a fascinating interplay between synthetic chemistry and biological activity. Here are some intriguing aspects:

  • Structural Complexity: The molecule features a unique octahydrocylcopenta[a]phenanthrene ring system, which is characteristic of many steroidal compounds. This complexity allows for a variety of biological interactions within the body.
  • Functional Groups: The presence of multiple functional groups, such as hydroxyl (-OH) and fluorine (F) atoms, contributes to the compound's potential as a medicinal agent, enhancing properties like solubility and biological activity.
  • Pharmaceutical Relevance: Compounds related to this structure can play a significant role in pharmaceuticals, particularly in the treatment of hormonal disorders and specific types of cancer. Their structural modifications are essential in the development of potent therapeutics.
  • Chirality: The specific stereochemistry indicated by the (9R,11S) configuration highlights the compound's chiral nature, which is critical for its interaction with biological targets. This emphasizes the importance of stereochemistry in drug design.
  • Historical Context: Similar compounds have been utilized in the field of endocrinology, affecting the research and treatment strategies for various diseases, showcasing the historical and ongoing significance in medical chemistry.

As a center of research, such compounds not only provide insight into biological mechanisms but also serve as a reminder of the intricate relationship between structure and function in medicinal chemistry. The study of this compound can pave the way for new therapeutic avenues and highlight the importance of continuous exploration in the ever-evolving field of chemistry.