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Fluocinolone acetonide

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Identification
Molecular formula
C24H30F2O6
CAS number
67-73-2
IUPAC name
[2-[(9R,11S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State
At room temperature, fluocinolone acetonide is in the form of a solid.
Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
494.00
Boiling point (Kelvin)
767.15
General information
Molecular weight
452.50g/mol
Molar mass
452.4970g/mol
Density
1.2400g/cm3
Appearence
Fluocinolone acetonide appears as a white to creamy white crystalline powder.
Comment on solubility

Solubility Overview

The compound 2-[(9R,11S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate presents interesting solubility characteristics influenced by its complex structure. Understanding the solubility of this compound is essential in predicting its behavior in various environments, especially in biological and industrial applications.

Factors Affecting Solubility

The solubility of this compound may be influenced by several factors:

  • Hydrophilicity vs. Hydrophobicity: The presence of hydrophilic groups such as the acetate and hydroxyl moieties can enhance water solubility, while the extensive carbon structure may hinder it.
  • Polarity: The balance of polar and nonpolar regions in the molecule plays a crucial role in determining its solubility in different solvents.
  • Temperature: Increasing temperature often facilitates higher solubility for many organic compounds, making it a key consideration.

Solubility in Common Solvents

While specific solubility data for this compound may not be readily available, similar compounds often exhibit the following general solubility patterns:

  • Soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), or acetone.
  • Limited solubility in aqueous environments, unless modified by specific conditions.

In conclusion, understanding the solubility of this compound is not only essential for its practical applications but also vital for further research in pharmacology and chemical sciences. The balance of its structural components necessitates a careful analysis of its solubility profile, which can dictate its potential use in various formulations and interactions within biological systems.

Interesting facts

Interesting Facts about 2-[(9R,11S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl Acetate

This remarkable compound belongs to the class of corticosteroids and has gained attention for its potent biological activities. Its intricate structure, consisting of a complex steroid framework, showcases the fascinating interplay of natural product chemistry and synthetic modification. Here are some intriguing facts about this compound:

  • Structural Diversity: The compound features a notable fluorine substitution at the 9th position, which can significantly enhance its biological activity and pharmacokinetic profiles.
  • Biochemical Significance: It acts similarly to hormones produced by the adrenal cortex, playing a crucial role in various physiological processes including metabolism and immune responses.
  • Therapeutic Use: This compound is often employed in treating inflammatory conditions, allergies, or even certain autoimmune disorders. Its effectiveness can lead to significant improvements in patients' quality of life.
  • Mechanism of Action: It primarily functions by binding to GLU (glucocorticoid receptor), modulating gene expression, and ultimately influencing the inflammatory response pathways.
  • Synthetic Routes: The complexity of the molecule presents challenges and opportunities for organic chemists, often leading to innovative synthetic methodologies to achieve this intricate structure efficiently.
  • Research Potential: Ongoing studies are being conducted to explore the compound's effects on various diseases and to identify possible derivatives that could yield even more potent pharmaceutical agents.

In summary, 2-[(9R,11S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate is not just a chemical entity; it's a testament to the evolution of medicinal chemistry and the pursuit of compounds that can tackle complex health challenges.