Skip to main content

Dexamethasone phosphate

ADVERTISEMENT
Identification
Molecular formula
C22H29Cl2FO7P
CAS number
2392-39-4
IUPAC name
[2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate
State
State

At room temperature, dexamethasone phosphate is typically in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
262.30
Melting point (Kelvin)
535.50
Boiling point (Celsius)
529.20
Boiling point (Kelvin)
802.30
General information
Molecular weight
516.40g/mol
Molar mass
516.3960g/mol
Density
1.3207g/cm3
Appearence

Dexamethasone phosphate is a white to off-white powder. It is often available as a solid suitable for sterilization and use in injectable solutions. The compound is odorless and hygroscopic.

Comment on solubility

Solubility of 2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate

The solubility of the compound 2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate can be influenced by several factors:

  • Polarity: As a phosphate derivative, the compound contains polar functional groups which can enhance its solubility in polar solvents such as water.
  • Hydrophilicity: The presence of the -OH (hydroxyl) group is likely to increase the hydrophilic character, promoting solubility in aqueous mediums.
  • Complex Formation: The potential for the phosphate group to form complexes with metal ions may also play a role in solubility dynamics, especially in saline solutions.
  • Temperature Influence: Like most chemical compounds, changes in temperature may affect solubility, often increasing it with rising temperatures.

In summary, while the exact solubility of this complex molecule is not commonly referenced, it is expected to exhibit variable solubility behavior depending on its environment due to its combination of hydrophilic and hydrophobic characteristics. Thus, testing under specific conditions is essential for accurate determination.

Interesting facts

Interesting Facts about 2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate

This remarkable compound is part of a larger class of chemicals known for their structural complexity and biological implications. It has drawn attention due to its potential applications in medicinal chemistry and its role in various biochemical processes.

Key Characteristics

  • Steroidal Framework: The compound features a steroid skeleton, which plays a crucial role in its biological activity.
  • Chlorinated Substituents: The presence of dichloro groups enhances its chemical reactivity and provides insight into its pharmacological properties.
  • Phosphate Group: The dihydrogen phosphate moiety is essential for its interaction with biological systems, particularly in cellular signaling.

Biological Significance

This compound has been studied for its potential as a therapeutic agent. Research indicates that modifications in its structure can influence:

  • Anticancer Activity: The unique arrangement of the steroid framework may contribute to its efficacy in targeting cancer cells.
  • Hormonal Functions: Similar compounds are often linked to hormone regulation, hinting at possible uses in endocrine therapies.

Quotes from Research

Researchers have noted, "The structural variations in steroid-like compounds allow for a diverse range of biological activities, making them promising candidates for drug development." This emphasizes the importance of understanding such compounds in the field of pharmacology.

In conclusion, this compound is more than just a complex molecular structure; it embodies potential breakthroughs in drug discovery and highlights the intricate relationship between chemistry and biology. Its unique characteristics warrant continued exploration in both academic and practical applications.

Synonyms
912U0LL2O2
16alpha-Methyldichlorisone phosphate
UNII-912U0LL2O2
18484-70-3
Pregna-1,4-diene-3,20-dione, 9,11-dichloro-17-hydroxy-16-methyl-21-(phosphonooxy)-, (11beta,16alpha)-
Pregna-1,4-diene-3,20-dione, 9,11beta-dichloro-17,21-dihydroxy-16alpha-methyl-, 21-(dihydrogen phosphate)