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Dexamethasone acetate

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Identification
Molecular formula
C24H31FO6
CAS number
1177-87-3
IUPAC name
[2-[(9R,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylene-3-oxo-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, dexamethasone acetate exists in a solid state. It is commonly encountered as a crystalline powder.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
579.90
Boiling point (Kelvin)
853.05
General information
Molecular weight
472.53g/mol
Molar mass
472.5330g/mol
Density
1.3700g/cm3
Appearence

Dexamethasone acetate appears as a white to off-white crystalline powder. It is practically odorless and stable under ordinary conditions of use and storage.

Comment on solubility

Solubility of [2-[(9R,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylene-3-oxo-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate

The solubility of the compound [2-[(9R,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylene-3-oxo-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate is influenced by several factors:

  • Polarity: Given that this compound contains both hydrophilic (such as hydroxyl groups) and lipophilic portions (aromatic rings), its solubility may vary significantly in water and organic solvents.
  • Solvent Type: It is likely to be more soluble in organic solvents like ethanol or methanol, where the hydrophobic regions can interact favorably.
  • Temperature: Increased temperature typically enhances solubility, particularly for organic compounds.
  • pH Sensitivity: The presence of hydroxyl groups may lead to changes in solubility at different pH levels, potentially affecting its interaction with water.

In summary, the solubility of this compound may be characterized as variable and dependent on environmental conditions and solvent choices. As stated, "Like dissolves like," meaning that the interplay between polar and nonpolar characteristics will significantly influence its solubility profile.

Interesting facts

Interesting Facts about 2-[(9R,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylene-3-oxo-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl Acetate

This complex compound is an intriguing member of the class of synthetic steroids, known for its unique structural features and potential biological activities. Here are some fascinating aspects:

  • Synthetic Analog: This compound is a synthetic derivative, suggesting its potential use in pharmaceutical applications, particularly in treatments that target hormonal pathways.
  • Fluorine Substitution: The presence of fluorine in its structure often enhances metabolic stability and alters biological activity, making it a subject of interest for medicinal chemists.
  • Hydroxyl Groups: The two hydroxyl groups introduce polar functional groups which can improve solubility in biological systems, potentially leading to increased bioactivity.
  • Structural Complexity: The intricate arrangement of fused rings and functional groups highlights the complexity that can be achieved in steroidal structures, often correlating with unique biological properties.

This compound illustrates the **remarkable diversity** within steroid-like molecules and their potential roles in **modern medicine**. As scientists continue to explore its properties, the balance of chemical modifications could lead to breakthroughs in drug design and therapeutic applications. The interplay of structure and activity in such compounds remains a rich field for continued research and discovery.

Quote: "Chemistry is not just a science of formulas and reactions; it's about understanding the intricate dance of atoms and how they express life." – Anonymous

Overall, 2-[(9R,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylene-3-oxo-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl acetate still holds many secrets that warrant investigation, making it an exciting topic for both students and seasoned researchers alike!

Synonyms
SCHEMBL1649450
NS00020970