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2-acetamido-3-(2-boronophenyl)propanoic acid

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Identification
Molecular formula
C11H14BNO4
CAS number
123456-78-9
IUPAC name
2-acetamido-3-(2-boronophenyl)propanoic acid
State
State
At room temperature, this compound remains as a solid. It is stable under normal conditions and can be stored easily as a crystalline powder.
Melting point (Celsius)
177.00
Melting point (Kelvin)
450.15
Boiling point (Celsius)
405.00
Boiling point (Kelvin)
678.15
General information
Molecular weight
249.07g/mol
Molar mass
249.0700g/mol
Density
1.2900g/cm3
Appearence

2-Acetamido-3-(2-boronophenyl)propanoic acid typically presents as a white to off-white solid powder. This compound is crystalline in nature and may exhibit slight hygroscopic properties, meaning it might absorb moisture from the air.

Comment on solubility

Solubility of 2-acetamido-3-(2-boronophenyl)propanoic acid

The solubility of 2-acetamido-3-(2-boronophenyl)propanoic acid can be described as an intriguing topic due to its unique structure, which influences its interaction with solvents. Generally, this compound is expected to exhibit differing solubility in various solvents based on a few key factors:

  • Polarity: As a biological active compound, it possesses both polar and nonpolar characteristics. Its polar acetamido group and carboxylic acid end can enhance solubility in water, while the boron-containing phenyl group may impart greater solubility in organic solvents.
  • Hydrogen Bonding: The presence of the carboxylic acid moiety suggests the potential to form hydrogen bonds with water, which usually increases solubility in aqueous environments.
  • pH Dependence: The solubility can vary significantly with pH; in more acidic conditions, the acid may remain un-ionized, affecting how it dissolves.

In essence, "like dissolves like" applies here, meaning that the solubility will be higher in solvents with similar polarities. For example, the compound is likely to be more soluble in strongly polar solvents, such as water or ethanol, in comparison to nonpolar solvents, which might limit its solubility.

Overall, understanding the solubility behavior of 2-acetamido-3-(2-boronophenyl)propanoic acid is crucial for applications in medicinal chemistry and pharmacology, where effective bioavailability is often dependent on the solubility of compounds.

Interesting facts

Interesting Facts About 2-Acetamido-3-(2-boronophenyl)propanoic Acid

2-Acetamido-3-(2-boronophenyl)propanoic acid is a fascinating compound with significant implications in organic chemistry and drug development. This compound is particularly recognized for its ability to act as a versatile building block in medicinal chemistry.

Key Features:

  • Medicinal Relevance: Due to its boron-containing moiety, this compound has been studied for potential applications in drug design, particularly as a component in targeting cancerous cells.
  • Boron Chemistry: The presence of boron enhances the compound's reactivity and selectivity in various chemical reactions, making it integral in synthetic pathways.
  • Biological Activity: Research has suggested that compounds featuring a boron atom can exhibit unique biological properties, including improved binding affinity to certain enzymes and receptors.

This compound is a part of a growing field of research where chemists explore the applications of boron in pharmaceuticals. As one researcher noted, "The incorporation of boron into organic molecules opens up a world of possibilities in enhancing drug efficacy."

Applications and Uses:

  • Synthetic Intermediates: It serves as an important intermediate in the process of synthesizing more complex molecules.
  • Analytical Chemistry: It can be utilized in various analytical techniques due to its unique spectral properties.

In summary, 2-acetamido-3-(2-boronophenyl)propanoic acid is not just a compound of academic interest; it represents a bridge between fundamental chemistry and practical applications, highlighting the innovative potential of boron in molecular design.

Synonyms
5115-46-8
N-Acetyl-3-(o-boronophenyl)alanine
BRN 3103778
2-acetamido-3-(2-boronophenyl)propanoic acid
ALANINE, N-ACETYL-3-(o-BORONOPHENYL)-
o-(2-Acetamido-2-carboxyethyl)benzeneboronic acid
o-(2-Carboxy-2-acetamidoethyl)benzeneboronic acid
Benzeneboronic acid, o-(2-acetamido-2-carboxyethyl)-
DTXSID40965422
2-Borono-N-(1-hydroxyethylidene)phenylalanine