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Chlorambucil

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Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
State
State

At room temperature, Chlorambucil is a solid compound. It needs to be stored under dry conditions to maintain its chemical integrity and stability.

Melting point (Celsius)
65.50
Melting point (Kelvin)
338.65
Boiling point (Celsius)
502.20
Boiling point (Kelvin)
775.35
General information
Molecular weight
304.67g/mol
Molar mass
304.6720g/mol
Density
1.2000g/cm3
Appearence

Chlorambucil appears as a pale yellow crystalline powder. It is slightly soluble in water and more soluble in alcohol, acetone, and lipids. Due to its strong chemical nature, it is handled with precautions in a laboratory setting.

Comment on solubility

Solubility of 2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

The solubility of 2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid presents an intriguing profile due to its complex molecular structure. Understanding its solubility characteristics can provide insight into its applications and behavior in various environments. Here are some important points to consider:

  • Polarity: This compound exhibits both polar and non-polar characteristics, which may affect its solubility in different solvents.
  • Water Solubility: Given its amide and carboxylic acid functionalities, it is likely to show some degree of solubility in water, although the presence of bulky substituents could limit this.
  • Organic Solvents: The compound may dissolve more readily in organic solvents such as dimethyl sulfoxide (DMSO) or dimethylformamide (DMF) due to enhanced interactions with non-polar regions.
  • Temperature Influence: Like many other compounds, an increase in temperature could enhance solubility, making it easier to dissolve.

As a rule of thumb, it’s often stated that “like dissolves like,” meaning that polar compounds will generally have better solubility in polar solvents, while non-polar compounds prefer non-polar solvents. For 2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid, its unique blend of functionalities suggests a moderate solubility behavior that merits further experimental investigation.

Interesting facts

Interesting Facts about 2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

This compound, also known for its role in medicinal chemistry, is of particular interest for its potential applications in pharmaceuticals. Here are some compelling facts that highlight its significance:

  • Medicinal Potential: This compound is related to anticancer agents, and its structure suggests promising activity against various types of tumors.
  • Mechanism of Action: The presence of the bis(2-chloroethyl)amino group is crucial, as it forms a reactive alkylating agent, which can interact with DNA, potentially stopping cancer cell proliferation.
  • Structure Activity Relationship (SAR): Understanding the precise influence of the acetamido and phenyl groups on the biological activity is a key area of research, helping scientists design more effective derivatives.
  • Analytical Techniques: Researchers utilize advanced analytical methods, such as NMR spectroscopy and mass spectrometry, to study the compound's dynamics and confirm its structure.
  • Research Significance: Ongoing studies explore this compound's role in targeted therapy, aiming to reduce side effects common in traditional chemotherapy.

With its intricate structure and promising pharmacological properties, 2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid exemplifies the exciting intersections of chemistry and medicine. As noted by many scientists, "The journey to understanding this compound may uncover new pathways to combat cancer." The ongoing work surrounding it emphasizes the critical importance of chemical innovation in advancing healthcare.

Synonyms
N-Acetylmelphalan
N-Acetylsarcolysine
Acetylsarcolysine
1160-90-3
5786-56-1
2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
DL-Phenylalanine, N-acetyl-4-[bis(2-chloroethyl)amino]-
N-Acmel
DL-Phenylalanine, N-acetyl-4-(bis(2-chloroethyl)amino)-
Phenylalanine, N-acetyl-4-(bis(2-chloroethyl)amino)-
NSC 212512
ALANINE, N-ACETYL-3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-
MLS000123340
SCHEMBL6661149
CHEMBL1406831
L-Phenylalanine, N-acetyl-4-[bis(2-chloroethyl)amino]-
DTXSID90921896
NZEYWBNQKCRBFO-UHFFFAOYSA-N
HMS2470G07
NSC154852
NSC212512
2-Acetylamino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid
AKOS000588937
AKOS024304113
NSC-154852
NSC-212512
NCGC00245095-01
SMR000124012
SR-01000319133
SR-01000319133-1
N-acetyl-4-[bis(2-chloroethyl)amino]-dl-phenylalanine
2-acetylamino-3-{4-[bis(2-chloroethyl)amino]phenyl}propionic acid
4-[Bis(2-chloroethyl)amino]-N-(1-hydroxyethylidene)phenylalanine
Alanine, N-acetyl-3-(p-(bis(2-chloroethyl)amino)phenyl)-, DL-