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Melphalan

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Identification
Molecular formula
C13H18Cl2N2O2
CAS number
148-82-3
IUPAC name
2-acetamido-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide
State
State

Melphalan is generally prepared and used as a solid, however, in clinical settings, it may be dissolved as a solution for intravenous administration.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
550.00
Boiling point (Kelvin)
823.15
General information
Molecular weight
305.21g/mol
Molar mass
305.2040g/mol
Density
1.3200g/cm3
Appearence

Melphalan exists as a white to off-white crystalline powder. It is finely divided with no specific odor.

Comment on solubility

Solubility of 2-acetamido-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide

The solubility of 2-acetamido-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide is a topic of interest as it offers insights into its behavior in various solvents. Understanding solubility is crucial for applications in drug formulation, chemical synthesis, and environmental science.

Key Points on Solubility

  • Polar vs. Non-Polar Solvents: This compound may exhibit variable solubility in polar and non-polar solvents due to the presence of both hydrophilic (amide groups) and hydrophobic (chloroethyl groups) characteristics.
  • pH Sensitivity: Its solubility can also be affected by pH levels; amide groups can interact differently with ions in solution, potentially increasing solubility in certain acidic or basic conditions.
  • Temperature Influence: Like many chemical compounds, solubility typically increases with temperature, suggesting that heating the solvent may enhance the dissolution of this specific compound.
  • Complex Formation: The compound might engage in complexation with metal ions or other agents, which would influence its solubility profile.

In conclusion, the solubility of 2-acetamido-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide depends on various factors including solvent type, pH, temperature, and potential interactions with other substances. Continued research is necessary to delineate its full solubility spectrum for practical applications.

Interesting facts

Interesting Facts about 2-acetamido-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide

2-acetamido-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide, often recognized for its role in medicinal chemistry, features a complex molecular structure that has attracted significant attention due to its potential in pharmaceutical applications. Here are some engaging aspects of this compound:

  • Potential Anticancer Agent: The compound is known to exhibit properties that may inhibit cancer cell proliferation, making it a candidate for further research in cancer therapeutics.
  • Mechanism of Action: The presence of the bis(2-chloroethyl)amino group is essential, as it is a common structural motif found in several cytotoxic agents, enabling DNA cross-linking that disrupts cell division.
  • Versatile Functionalities: With the acetamido groups present, this compound can serve as a versatile building block for synthesizing various derivatives, potentially enhancing therapeutic efficacy or reducing toxicity.
  • Research Potential: Scientists are continuously exploring its applications in drug design, focusing on modifying its structure to optimize the balance between efficacy and safety.

As noted by researchers, "The chemistry of nitrogen-containing compounds like this one is pivotal in advancing our understanding of drug mechanisms." This emphasizes the importance of compounds in the search for new and better therapeutic options in medicine.

Overall, 2-acetamido-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide exemplifies how complex organic compounds can lead to significant breakthroughs in healthcare, underlining the critical role of chemistry in enhancing human health.

Synonyms
BRN 2820301
ACETANILIDE, 2-ACETAMIDO-4'-(BIS(2-CHLOROETHYL)AMINO)-
3131-19-9
2-Acetamido-4'-(bis(2-chloroethyl)amino)acetanilide
DTXSID00185240
DTXCID10107731