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Fluorobiprofen

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Identification
Molecular formula
C15H11FO4
CAS number
67914-60-7
IUPAC name
2-acetoxy-5-(4-fluorophenyl)benzoic acid
State
State

At room temperature, fluorobiprofen is in a solid state, predominantly as a crystalline powder.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.20
Boiling point (Celsius)
766.10
Boiling point (Kelvin)
1 039.30
General information
Molecular weight
274.24g/mol
Molar mass
274.2430g/mol
Density
1.3473g/cm3
Appearence

Fluorobiprofen is typically a white to off-white crystalline powder. It appears as a fine solid and may have a slightly characteristic odor depending on its synthesis and purity.

Comment on solubility

Solubility of 2-acetoxy-5-(4-fluorophenyl)benzoic acid

The solubility of 2-acetoxy-5-(4-fluorophenyl)benzoic acid can be influenced by its chemical structure. This compound features both hydrophilic and hydrophobic characteristics, which play significant roles in its solubility behavior.

Factors Affecting Solubility:

  • Polar Groups: The presence of the acetoxy group contributes to hydrogen bonding, enhancing its solubility in polar solvents such as water.
  • Nonpolar Character: The 4-fluorophenyl component introduces a nonpolar characteristic, which may limit its solubility in polar solvents.
  • pH Influence: The acid's dissociation can also be influenced by the pH of the solution, potentially increasing solubility in basic conditions.

Overall, while 2-acetoxy-5-(4-fluorophenyl)benzoic acid is somewhat soluble in polar solvents due to its functional groups, its solubility may vary significantly based on environmental factors. As a general observation, it is less soluble in nonpolar solvents. Hence, predictions regarding solubility should consider both the polar and nonpolar aspects of the compound.

Interesting facts

Exploring 2-acetoxy-5-(4-fluorophenyl)benzoic acid

2-acetoxy-5-(4-fluorophenyl)benzoic acid is a compound that attracts interest due to its unique structure and potential applications in various fields of chemistry. Here are some fascinating facts about this intriguing molecule:

  • Chemical Family: This compound belongs to the class of benzoic acids, which are known for their aromatic features and diverse biological activities.
  • Pharmacological Potential: Compounds of this type can exhibit a range of therapeutic properties. They may act as anti-inflammatory agents, making them candidates for pharmaceutical development.
  • Fluorine's Influence: The presence of the 4-fluorophenyl group is particularly noteworthy. Fluorine is known to modify the electronic properties of molecules, enhancing their reactivity and stability. This can lead to improved pharmacokinetics in drug formulations.
  • Application in Research: Such compounds are often utilized in medicinal chemistry to explore new drug candidates. Researchers frequently investigate the ester and acid functionalities for their biological interactions.
  • Structure-Activity Relationship: Understanding the effects of various substituents on the benzoic acid core allows chemists to deduce how structural changes can lead to different biological outcomes, paving the way for optimized drug design.

In summary, 2-acetoxy-5-(4-fluorophenyl)benzoic acid stands out for its multifaceted applications and intriguing chemical properties. As research continues to unveil new insights, this compound could contribute significantly to advancements in medicinal chemistry and therapeutic development.

Synonyms
FLUFENISAL
22494-27-5
2-acetyloxy-5-(4-fluorophenyl)benzoic acid
4U3WU1RD0W
DTXSID30177017
4'-Fluoro-4-hydroxy-3-biphenylcarboxylic acid acetate
(1,1'-Biphenyl)-3-carboxylic acid, 4-(acetyloxy)-4'-fluoro-
[1,1'-Biphenyl]-3-carboxylicacid, 4-(acetyloxy)-4'-fluoro-
Flufenisal [USAN:INN]
UNII-4U3WU1RD0W
flufenisalum
FLUFENISAL [INN]
Flufenisal (USAN/INN)
FLUFENISAL [USAN]
RefChem:1085408
SCHEMBL38781
CHEMBL2104904
DTXCID2099508
XKSAJZSJKURQRX-UHFFFAOYSA-N
2-acetoxy 5-(4'-fluorophenyl)-benzoic acid
D04206
Q27260498
4-Acetoxy-4'-fluoro-[1,1'-biphenyl]-3-carboxylic acid