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Aspirin, Paracetamol, Caffeine Combination

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Identification
Molecular formula
C9H8O4 (Aspirin), C8H9NO2 (Paracetamol), C8H10N4O2 (Caffeine)
CAS number
Not applicable
IUPAC name
2-acetoxybenzoic acid;N-(4-ethoxyphenyl)acetamide;1,3,7-trimethylpurine-2,6-dione
State
State

At room temperature, this combination is typically found as a solid, existing as a fine white powder due to the powdered state of each individual component: aspirin, paracetamol, and caffeine.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.00
Boiling point (Celsius)
178.00
Boiling point (Kelvin)
451.00
General information
Molecular weight
308.36g/mol
Molar mass
308.3640g/mol
Density
1.4000g/cm3
Appearence

The appearance of this combination compound is typically that of a white crystalline powder. Each of the individual compounds, aspirin, paracetamol, and caffeine contribute to this appearance. Aspirin is usually a white crystalline powder or granules, paracetamol appears as a white, odorless, crystalline solid, and caffeine is a white, odorless, crystalline powder or needles.

Comment on solubility

Solubility of 2-acetoxybenzoic acid

2-acetoxybenzoic acid (C9H10O3), commonly known as acetylsalicylic acid or aspirin, exhibits notable solubility characteristics:

  • Generally soluble in organic solvents such as ethanol and acetone.
  • Partially soluble in water, particularly at elevated temperatures.
  • Solubility is impacted by pH; being more soluble in alkaline conditions.

This is important for its pharmacological efficacy, where dissolution rate can influence absorption in the body.


Solubility of N-(4-ethoxyphenyl)acetamide

N-(4-ethoxyphenyl)acetamide (C12H15N1O2), often associated with various drug designs, shows specific solubility traits:

  • Usually exhibits moderate solubility in polar solvents.
  • Low solubility in non-polar solvents, which can hinder its application in certain formulations.

The solubility profile of this compound is crucial for its development in pharmaceutical applications, determining how effectively it can interact with biological systems.


Solubility of 1,3,7-trimethylpurine-2,6-dione

1,3,7-trimethylpurine-2,6-dione (C7H9N5O2), commonly known as caffeine, presents interesting solubility behaviors:

  • Highly soluble in water, making it easily absorbable in biological contexts.
  • Soluble in organic solvents like ethanol and chloroform.
  • Temperature plays a key role; solubility increases with higher temperatures.

The widespread solubility of caffeine contributes to its rapid onset of action in physiological effects, which is significant in both food and pharmaceutical industries.

Interesting facts

2-Acetoxybenzoic Acid

2-Acetoxybenzoic acid, more commonly known as aspirin, is a fascinating compound renowned for its medicinal properties. Originally derived from willow bark, this compound plays a vital role in modern medicine.

Here are some intriguing facts about 2-acetoxybenzoic acid:

  • Pain relief: Aspirin is widely recognized for its ability to alleviate pain and reduce inflammation, making it a staple in the pharmaceutical industry.
  • Antipyretic properties: It is effective in lowering fevers, thus proving invaluable in treating various illnesses.
  • Cardiovascular benefits: Low doses of aspirin are often prescribed to reduce the risk of heart attacks and strokes by preventing blood clots.
  • Historical significance: Its use dates back to ancient civilizations, and its synthesis marked a pivotal moment in the evolution of synthetic organic chemistry!

In the words of renowned chemist Sir John Vane, who won the Nobel Prize for his discoveries relating to aspirin: "Aspirin works by inhibiting an enzyme involved in the production of prostaglandins, thereby reducing pain and inflammation."

N-(4-Ethoxyphenyl)acetamide

N-(4-Ethoxyphenyl)acetamide, less frequently discussed, still offers compelling insights into organic chemistry. This compound is particularly interesting due to its potential uses and the structural complexity of its molecules.

Exploring its riveting characteristics:

  • Structural uniqueness: It features an ethoxy group, which contributes to its distinctive reactivity and solubility properties.
  • Potential applications: Compounds like this are often researched for their pharmacological possibilities and might have roles in the synthesis of various therapeutic agents.
  • Research interest: It is often used in studies to understand the interactions between different functional groups and their resulting biological activities.

This compound emphasizes the creativity and diversity found within amide chemistry, showcasing how subtle changes in structure can yield vastly different properties and applications.

1,3,7-Trimethylpurine-2,6-dione

1,3,7-Trimethylpurine-2,6-dione is a compound with a notable role in biochemistry, primarily recognized as **caffeine**. Beloved worldwide, it is not just a stimulant but also a subject of extensive scientific study.

Consider these captivating features:

  • Stimulant effects: Caffeine interacts with the central nervous system to enhance alertness and reduce fatigue.
  • Wide occurrence: This compound is prevalent in coffee, tea, and various soft drinks, contributing to its global popularity.
  • Health research: Numerous studies suggest potential benefits, including improved cognitive function and decreased risk of certain diseases, if consumed in moderation.
  • Cultural impact: Caffeine has significantly shaped cultural habits and social interactions, epitomized in the coffeehouse culture that blossomed in Europe.

As a chemist, it’s enthralling to explore how such a simple organic structure can have profound effects on society and our day-to-day lives. Caffeine serves as a sign of the intricate relationship between chemistry and human culture.

Synonyms
Benzoic acid, 2-(acetyloxy)-, mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione and N-(4-ethoxyphenyl)acetamide
Thomapyrin
8003-03-0
Aspirin mixt. with phenacetin and caffeine
Bex powder
Ascophen
Askophen
Citramon
Oscophen
APC (pharmaceutical)
APC.
CCRIS 50
A.P.C
Aspirin, phenacetin and caffeine
Aspirin, phenacetin, and caffeine
NCI-C02697
aspirin - caffeine - phenacetin
2-acetyloxybenzoic acid;N-(4-ethoxyphenyl)acetamide;1,3,7-trimethylpurine-2,6-dione