Skip to main content

Trifluoro Phenyl Ethanolamine

ADVERTISEMENT
Identification
Molecular formula
C9H10F3NO
CAS number
20776-51-6
IUPAC name
2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
State
State

At room temperature, 2-amino-1-[3-(trifluoromethyl)phenyl]ethanol is typically a crystalline solid.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.15
Boiling point (Celsius)
291.00
Boiling point (Kelvin)
564.15
General information
Molecular weight
205.18g/mol
Molar mass
205.1760g/mol
Density
1.3395g/cm3
Appearence

2-amino-1-[3-(trifluoromethyl)phenyl]ethanol appears as a white to off-white crystalline solid. It may have a faint aromatic odor that is often characteristic of aromatic amines.

Comment on solubility

Solubility of 2-amino-1-[3-(trifluoromethyl)phenyl]ethanol

2-amino-1-[3-(trifluoromethyl)phenyl]ethanol is a compound whose solubility characteristics can significantly influence its applications in various fields, such as pharmaceuticals and chemical synthesis. Here are some key points to consider:

  • Polar Nature: The presence of both the amino group and hydroxyl group in the structure contributes to the molecule's polarity, which generally enhances solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl (-OH) group allows for the formation of hydrogen bonds with water molecules, which plays a crucial role in solubility.
  • Trifluoromethyl Group: The trifluoromethyl (-CF3) substituent introduces lipophilic characteristics. This could potentially decrease solubility in aqueous environments compared to non-fluorinated analogs.
  • Temperature Effects: Like many chemicals, solubility may vary with temperature; increased temperatures often improve solubility for many compounds.

In summary, while 2-amino-1-[3-(trifluoromethyl)phenyl]ethanol is likely to be soluble in polar solvents due to its functional groups, the influence of the trifluoromethyl group may affect its overall solubility profile. Understanding these solubility dynamics is essential for utilizing this compound effectively in practical applications.

Interesting facts

Interesting Facts About 2-amino-1-[3-(trifluoromethyl)phenyl]ethanol

2-amino-1-[3-(trifluoromethyl)phenyl]ethanol is a fascinating chemical compound that combines elements of both pharmaceutical and fluorinated chemistry. Below are some noteworthy insights:

  • Pharmacological Potential: Compounds like 2-amino-1-[3-(trifluoromethyl)phenyl]ethanol often serve as building blocks in drug design due to their ability to interact with biological systems. The presence of the amino group can facilitate hydrogen bonding, impacting the compound's biological activity.
  • Fluorinated Innovations: The trifluoromethyl group is known for enhancing the metabolic stability and lipophilicity of compounds, making them particularly valuable in medicinal chemistry. This group can alter the electronic properties and solubility behavior, resulting in compounds with unique characteristics.
  • Versatile Applications: Beyond pharmaceuticals, this compound may also have applications in agrochemicals and materials science due to its distinctive structure.
  • Structure-Activity Relationships (SAR): Understanding the influence of different substituents, such as the trifluoromethyl group, on the compound's activity can provide insights into optimizing pharmacological efficacy.
  • Synthetic Pathways: The synthesis of such compounds can introduce students to advanced synthetic techniques, demonstrating the interplay between organic synthesis and functional group chemistry.

To quote a notable chemist, "The beauty of chemistry lies in its ability to create novel entities that can alter our understanding of life itself." This sentiment rings true for compounds like 2-amino-1-[3-(trifluoromethyl)phenyl]ethanol, where the combination of structural features leads to potential breakthroughs in drug discovery and development.

Synonyms
DTXSID00943504
2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol
2-amino-1-(3-(trifluoromethyl)phenyl)ethan-1-ol
RefChem:463250
DTXCID101371869
992-077-0
21172-28-1
2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
Benzenemethanol, a-(aminomethyl)-3-(trifluoromethyl)-
MFCD01664407
CHEMBL224618
2-amino-1-(3-(trifluoromethyl)phenyl)ethanol
3-trifluoromethylphenylethanolamine
2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine
BRN 2806670
(S)-2-Amino-1-(3-(trifluoromethyl)phenyl)ethan-1-ol
alpha-Aminomethyl-m-trifluoromethylbenzyl alcohol
SCHEMBL166671
SCHEMBL30753488
BENZYL ALCOHOL, alpha-AMINOMETHYL-m-TRIFLUOROMETHYL-
RRBRWAPWPGAJMA-UHFFFAOYSA-O
BDBM50176888
AKOS005265622
BS-12599
PD038074
SY154506
2-amino-1-(3-trifluoromethylphenyl)ethanol
C78045
EN300-145628
2-(3-trifluoromethylphenyl)-2-hydroxyethanamine
2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine
2-hydroxy-2-(3-trifluoromethylphenyl)-ethanamine
alpha-(Aminomethyl)-3-(Trifluoromethyl)-Benzenemethanol