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Norepinephrine

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Identification
Molecular formula
C8H11NO3
CAS number
51-41-2
IUPAC name
2-amino-1-(3,4-dihydroxyphenyl)ethanone
State
State

At room temperature, norepinephrine is typically found in a solid form. Its crystalline structure is characteristic of many small organic compounds.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
243.00
Boiling point (Kelvin)
516.15
General information
Molecular weight
153.18g/mol
Molar mass
153.1790g/mol
Density
1.2830g/cm3
Appearence

Norepinephrine is a colorless to white crystalline powder. It may appear slightly yellowish when in impure form. It is typically sensitive to air and light, which can cause discoloration.

Comment on solubility

Solubility of 2-amino-1-(3,4-dihydroxyphenyl)ethanone

2-amino-1-(3,4-dihydroxyphenyl)ethanone, often referred to as a small molecule derivative influenced by the presence of hydroxyl groups, exhibits intriguing solubility characteristics. Understanding its solubility is paramount for applications in both pharmaceutical and chemical research.

Key Points on Solubility:

  • Polar Nature: Due to the presence of multiple hydroxyl groups, this compound is expected to be polar, which typically enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl (-OH) groups can form hydrogen bonds with solvent molecules, further promoting solubility.
  • Solvent Dependence: Solubility may vary significantly depending on the solvent. For instance, it is likely to be soluble in ethanol and methanol, while less soluble in non-polar solvents.
  • Temperature Influence: Increased temperature often leads to greater solubility; thus, this compound might dissolve better at elevated temperatures.

In summary, the solubility of 2-amino-1-(3,4-dihydroxyphenyl)ethanone is influenced by its polar structure and the ability to engage in hydrogen bonding, making it soluble primarily in polar solvents while exhibiting variability affected by temperature and solvent type.

Interesting facts

Interesting Facts about 2-amino-1-(3,4-dihydroxyphenyl)ethanone

2-amino-1-(3,4-dihydroxyphenyl)ethanone, commonly referred to as a derivative of tyrosine, has garnered significant attention within the fields of biochemistry and medicinal chemistry. This compound is particularly noteworthy for its incorporation of both amino and hydroxy functional groups, leading to versatile reactivity and biological activity. Here are some fascinating aspects to consider:

  • Natural Precursor: This compound is structurally related to the amino acid tyrosine, which is a precursor for important biological molecules such as dopamine, norepinephrine, and epinephrine, making it integral to neurochemistry.
  • Phenolic Antioxidant: The presence of the dihydroxyphenyl group endows this compound with antioxidant properties. It can scavenge free radicals, potentially providing protective effects against oxidative stress.
  • Potential Therapeutic Applications: Research into this compound has suggested potential applications in treating neurodegenerative diseases and mental health disorders due to its influence on neurotransmitter synthesis.
  • Synthetic Versatility: The ability to modify the amino and hydroxy groups allows for the development of various analogs, which can be tailored to enhance specific biological activities or reduce side effects.
  • Research Significance: This compound helps in the study of metabolic pathways and enzyme functions related to amino acid metabolism, especially in the context of human health.

Overall, 2-amino-1-(3,4-dihydroxyphenyl)ethanone represents a striking example of how simple modifications in chemical structure can lead to significant impacts on biological activity and therapeutic potential. As research continues to advance, this compound may unlock new pathways for medical applications.

Synonyms
499-61-6
2-Amino-1-(3,4-dihydroxyphenyl)ethanone
Noradrenalone
Arterenone
2-Amino-1-(3,4-dihydroxyphenyl)ethan-1-one
Ethanone, 2-amino-1-(3,4-dihydroxyphenyl)-
2-Amino-3',4'-dihydroxyacetophenone
RHR76MLA92
Arterenon
EINECS 207-883-3
U 0603
Noradrenalone (arterenone)
BRN 2719260
ADROLOP
UNII-RHR76MLA92
ACETOPHENONE, 2-AMINO-3',4'-DIHYDROXY-
SCHEMBL1703207
DTXSID10198144
AKOS006275024
DB-087236
NS00031985
A10825
U-0603
NORADRENALINE TARTRATE IMPURITY B [EP IMPURITY]