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4'-Bromoacetophenone

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Identification
Molecular formula
C8H7BrNO
CAS number
99-90-1
IUPAC name
2-amino-1-(4-bromophenyl)ethanone
State
State

At room temperature, 4'-Bromoacetophenone is a solid. It maintains its structure well under normal conditions but may sublimate slightly if left uncontained over time. It is essential to store it in a dry, cool place to prevent any degradation or loss of compound integrity.

Melting point (Celsius)
47.00
Melting point (Kelvin)
320.15
Boiling point (Celsius)
273.00
Boiling point (Kelvin)
546.15
General information
Molecular weight
199.05g/mol
Molar mass
199.0470g/mol
Density
1.5100g/cm3
Appearence

4'-Bromoacetophenone typically appears as a pale yellow crystalline solid. The crystals are generally fine and can be handled in powdered form or as a larger aggregate of crystals. Its distinct color and structure can aid in identification in a laboratory setting.

Comment on solubility

Solubility of 2-amino-1-(4-bromophenyl)ethanone

The solubility of 2-amino-1-(4-bromophenyl)ethanone can be influenced by various factors including temperature, pH, and the solvent used. In general, this compound exhibits the following solubility characteristics:

  • Solvent Polarity: Due to the presence of both polar and nonpolar functional groups, it tends to dissolve well in polar organic solvents.
  • Aqueous Solubility: The amine group may impart some degree of solubility in water, although it is not highly soluble, particularly at room temperature.
  • Temperature Dependency: Increased temperatures typically enhance solubility; thus, heating the solvent may improve the dissolution of this compound.
  • pH Influence: The solubility can be affected by the pH of the solution; it might have better solubility in acidic conditions due to protonation of the amine group.

In summary, while 2-amino-1-(4-bromophenyl)ethanone shows some solubility in polar solvents, it is essential to consider environmental conditions for optimal dissolution. Understanding the solubility profile of this compound can aid in its application in various chemical processes.

Interesting facts

Interesting Facts about 2-amino-1-(4-bromophenyl)ethanone

2-amino-1-(4-bromophenyl)ethanone, often abbreviated as ABPE, is a fascinating compound that has garnered attention in various fields, particularly in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Pharmacological Interest: ABPE has been studied for its potential biological activities, demonstrating significant promise in drug development, particularly as an anti-cancer agent.
  • Structural Features: The presence of the bromine atom in the para position of the phenyl ring enhances the compound's electrophilic characteristics, potentially influencing its reactivity and biological interactions.
  • Amino Group Significance: The amino group attached to the ethanone carbon serves as an important functional site, which can participate in hydrogen bonding and contribute to the compound's solubility and interaction with biological molecules.
  • Synthetic Routes: There are various synthetic methods to obtain ABPE, which often involve substitution reactions. Understanding these pathways is crucial for developing more efficient synthesis strategies in the laboratory.
  • Research Applications: Beyond its pharmacological potential, ABPE is utilized in organic synthesis as a building block for constructing complex molecules in chemical research.

"Understanding compounds like 2-amino-1-(4-bromophenyl)ethanone is essential for advancing the field of organic and medicinal chemistry."

Its wide array of applications makes 2-amino-1-(4-bromophenyl)ethanone a compound worth exploring for researchers and students alike. The interplay between its structure and biological activity continues to be a rich area for further investigation.

Synonyms
2-amino-1-(4-bromophenyl)ethanone
7644-04-4
DTXSID70274711
DTXCID90226171
2-Amino-4'-bromoacetophenone
Ethanone, 2-amino-1-(4-bromophenyl)-
CHEMBL1801613
2-Amino-4'-bromoacetophenone; Aminomethyl 4-Bromophenyl ketone; Aminomethyl p-bromophenyl ketone
2-Amino-4 inverted exclamation mark -bromoacetophenone
47A
MFCD00994527
2-amino-1-(4-bromophenyl)ethan-1-one
Maybridge1_001114
2-amino 4'-bromoacetophenone
SCHEMBL205675
CHEMBL1851811
ZQFATRVLQKIVTH-UHFFFAOYSA-N
CS-B1499
BDBM50347510
STL353645
2-amino-1-(4-bromo-phenyl)ethanone
AKOS005208150
2-Amino-1-(4-bromo-phenyl)-ethanone
NCGC00188135-01
SY282724
EN300-134401
AE-848/00959051
Q27454465