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2-Amino-1-(4-fluorophenyl)ethanol

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Identification
Molecular formula
C8H10FNO
CAS number
402-49-3
IUPAC name
2-amino-1-(4-fluorophenyl)ethanol
State
State

2-Amino-1-(4-fluorophenyl)ethanol is a solid at room temperature. It is often handled as a crystalline powder or granulate.

Melting point (Celsius)
51.00
Melting point (Kelvin)
324.20
Boiling point (Celsius)
278.30
Boiling point (Kelvin)
551.50
General information
Molecular weight
155.17g/mol
Molar mass
155.1740g/mol
Density
1.2556g/cm3
Appearence

2-Amino-1-(4-fluorophenyl)ethanol is typically found as a white to off-white crystalline solid. It has a distinct appearance owing to its crystalline structure, and the presence of the fluorophenyl group can occasionally impart a slightly different hue.

Comment on solubility

Solubility of 2-amino-1-(4-fluorophenyl)ethanol

2-amino-1-(4-fluorophenyl)ethanol, with its chemical formula C8H10F1N1O1, displays interesting solubility characteristics that make it noteworthy in various chemical applications.

This compound is generally considered to be:

  • Soluble in Water: Due to the presence of the amino group (-NH2) and the hydroxyl group (-OH), 2-amino-1-(4-fluorophenyl)ethanol exhibits significant hydrogen bonding capabilities, enhancing its solubility in polar solvents like water.
  • Moderately Soluble in Alcohols: The compound also finds decent solubility in alcohols due to its functional groups, which can interact favorably with the hydroxylic nature of alcohols.
  • Poorly Soluble in Non-polar Solvents: Conversely, 2-amino-1-(4-fluorophenyl)ethanol displays limited solubility in non-polar solvents, which is typical for compounds containing polar functional groups.

In conclusion, the solubility of 2-amino-1-(4-fluorophenyl)ethanol is a reflection of its ability to form hydrogen bonds and interact with polar solvents. Thus, understanding its solubility can influence its behavior in various chemical reactions and applications.

Interesting facts

Interesting Facts about 2-amino-1-(4-fluorophenyl)ethanol

2-amino-1-(4-fluorophenyl)ethanol is a fascinating compound that plays a significant role in the field of medicinal chemistry. Here are some intriguing points to consider:

  • Pharmaceutical Relevance: This compound is often studied for its potential as a precursor in the synthesis of various pharmaceuticals, particularly in the development of drugs targeting neurological disorders.
  • Structural Features: The combination of an amino group and a phenyl ring with a fluorine substituent demonstrates diverse reactivity and interaction with biological targets. Such structural features often influence the compound's biological activity and its ability to cross the blood-brain barrier.
  • Fluorine Atom: The presence of the fluorine atom in the para position of the phenyl ring is noteworthy. Fluorinated compounds often exhibit enhanced lipophilicity and metabolic stability, making them valuable in drug design.
  • Research Applications: Studies have indicated that the compound may influence neurotransmitter systems, making it a potential candidate for treating conditions like depression or anxiety. Researchers are particularly interested in its effects on serotonin and norepinephrine levels.
  • Synthetic Pathways: The methods for synthesizing 2-amino-1-(4-fluorophenyl)ethanol often involve employing various catalytic reactions, which showcase the compound's accessibility for research and pharmaceutical applications.

In summary, 2-amino-1-(4-fluorophenyl)ethanol is not just another compound; it stands at the intersection of chemistry and pharmacology, providing scientists with a platform to innovate and explore new therapeutic avenues. Its unique characteristics and potential applications continue to inspire research worldwide.

Synonyms
456-05-3
2-amino-1-(4-fluorophenyl)ethanol
2-amino-1-(4-fluorophenyl)ethan-1-ol
2-Amino-1-(4-fluorophenyl)-1-ethanol
Benzenemethanol, a-(aminomethyl)-4-fluoro-
alpha-(Aminomethyl)-4-fluorobenzyl alcohol
MFCD08056632
4-fluoro-phenylethanolamine
BENZENEMETHANOL,|A-(AMINOMETHYL)-4-FLUORO-
SCHEMBL297244
DTXSID00274502
LPKXWVNNGWDLMT-UHFFFAOYSA-N
p-FLUOROPHENYLALANINE_met006
2-amino-1-(4-fluoro-phenyl)-ethanol
AKOS000123727
AKOS016051388
alpha-(aminomethyl)-p-fluorobenzyl alcohol
DB-227095
[rac]-2-amino-1-(4-fluoro-phenyl)-ethanol
CS-0452649
EN300-36694
C78230
AB01002495-01
4Z-0721
825-674-0