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Phenylacetone

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Identification
Molecular formula
C9H10O
CAS number
103-79-7
IUPAC name
2-amino-1-phenyl-ethanone
State
State

Phenylacetone is a liquid at room temperature. It is often used as an intermediate chemical in various organic syntheses and requires careful handling due to its liquid state.

Melting point (Celsius)
-15.00
Melting point (Kelvin)
258.15
Boiling point (Celsius)
216.00
Boiling point (Kelvin)
489.15
General information
Molecular weight
134.18g/mol
Molar mass
134.1780g/mol
Density
1.0600g/cm3
Appearence

Phenylacetone is a colorless to pale yellow oil. It is often clear, but can appear slightly yellowish due to impurities. In its pure form, it should be transparent with no solid particles.

Comment on solubility

Solubility of 2-amino-1-phenyl-ethanone

2-amino-1-phenyl-ethanone, also known as acetophenone hydrazone, demonstrates interesting solubility characteristics that are key to its chemical behavior:

  • Solvent Dependence: This compound is generally soluble in polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). It exhibits limited solubility in non-polar solvents.
  • Temperature Influence: The solubility tends to increase with rising temperatures, allowing for better dissolution in solvents.
  • pH Sensitivity: The presence of an amino group makes its solubility sensitive to pH changes, which can influence protonation states and therefore affect solubility drastically.

As noted in a study, "the solubility of organic compounds is crucial for their applications in pharmaceutical formulations," indicating that understanding the solubility of compounds like 2-amino-1-phenyl-ethanone is vital for their practical utilization.

In summary, the solubility of 2-amino-1-phenyl-ethanone in various solvents plays a significant role in its applications and effectiveness in chemical processes, particularly in organic synthesis and pharmaceutical development.

Interesting facts

Interesting Facts about 2-amino-1-phenyl-ethanone

2-amino-1-phenyl-ethanone, commonly known as phenylacetone or phenyl-2-propanone, is a fascinating organic compound with significant relevance in both academic and industrial applications. Here are some intriguing aspects that highlight its importance:

  • Synthesis and Applications: This compound serves as a crucial intermediate in the synthesis of various pharmaceuticals, particularly in the production of amphetamines. Its versatility makes it a valuable building block in organic synthesis.
  • Structural Features: The compound is characterized by both an amino and a ketone functional group, which contributes to its reactivity. The presence of the phenyl group also enhances its biological activity, making it a topic of interest for medicinal chemistry.
  • Historical Significance: 2-amino-1-phenyl-ethanone is historically significant due to its association with illegal drug manufacturing. This connection has led to strict regulations on its production and distribution in various countries, making it a subject of interest in forensic chemistry.
  • Research Area: Current research continues to explore the compound's potential in areas such as drug development, with scientists investigating its effects and mechanisms at the molecular level.
  • Analytical Techniques: The study of this compound often involves advanced analytic techniques like NMR spectroscopy and mass spectrometry, providing insights into its structure and properties.

Overall, 2-amino-1-phenyl-ethanone presents a unique blend of chemistry, history, and practical applications, making it a noteworthy compound within the realm of chemical sciences.

Synonyms
2-Aminoacetophenone
Phenacylamine
613-89-8
2-Amino-1-phenylethanone
2-Amino-1-phenylethan-1-one
2-Aminoecetophenone
Ethanone, 2-amino-1-phenyl-
2-amino-1-phenyl-ethanone
alpha-Aminoactophenone
alpha-Aminoacetophenone
alpha-Demethylcathinone
omega-Aminoacetophenone
ACETOPHENONE, 2-AMINO-
.omega.-Aminoacetophenone
4M571C83H7
MLS002207080
2-amino acetophenone
2-amino-1-phenylethanone;hydrochloride
SMR001306710
EINECS 210-358-1
1-Phenyl-2-aminoethanone
BRN 0507952
Phenomydrol
aminoacetophenone
Benzoylmethylamine
UNII-4M571C83H7
amino acetophenone
2-oxophenethylamine
2amino-acetophenone
2-Amino-acetophenone
Spectrum_001806
Spectrum2_001993
Spectrum3_001033
Spectrum4_001167
Spectrum5_001836
2-amino-1phenyl-ethanone
2-oxo-2-phenylethanamine
2-oxo-2-phenylethylamine
PHENACYLAMINE [MI]
2-amino-1 phenyl-ethanone
2-AAP
2-oxo-2-phenyl-ethyl-amine
SCHEMBL45515
2-Amino-1-phenylethanone #
BSPBio_002845
KBioGR_001773
KBioSS_002299
4-14-00-00114 (Beilstein Handbook Reference)
SPBio_002205
CHEMBL128079
SCHEMBL9855165
.ALPHA.-AMINOACETOPHENONE
.ALPHA.-DEMETHYLCATHINONE
2-Amino-1-phenylethanone, 9CI
BDBM96824
cid_2723597
KBio2_002297
KBio2_004865
KBio2_007433
KBio3_002065
DTXSID80210206
CHEBI:104022
(2-OXO-2-PHENYLETHYL)AMINE
BBL028098
STK684967
ACETOPHENONE, .ALPHA.-AMINO-
AKOS004114654
SDCCGMLS-0066907.P001
2-amino-1-phenyl-ethanone;hydrochloride
2-azanyl-1-phenyl-ethanone;hydrochloride
NCGC00178437-01
NCGC00178437-02
AC-22359
BP-21393
NS00034671
BRD-K61831307-003-02-1
Q27181279