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Norephedrine

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Identification
Molecular formula
C9H13NO
CAS number
122-57-6
IUPAC name
2-amino-1-phenyl-propan-1-ol
State
State

At room temperature, norephedrine is typically found in a crystalline solid state. Its formulation as a hydrochloride or sulfate salt can influence its solubility and application, but does not change its solid-state form at room temperature.

Melting point (Celsius)
74.00
Melting point (Kelvin)
347.15
Boiling point (Celsius)
218.00
Boiling point (Kelvin)
491.15
General information
Molecular weight
151.21g/mol
Molar mass
151.2110g/mol
Density
1.0925g/cm3
Appearence

Norephedrine appears as a white or almost white crystalline solid. It is typically provided as a hydrochloride or sulfate salt, depending on specific formulations. In its pure form, it is water-soluble and has a bitter taste.

Comment on solubility

Solubility of 2-amino-1-phenyl-propan-1-ol (C9H13NO)

The solubility of 2-amino-1-phenyl-propan-1-ol presents an intriguing profile due to its functional groups and molecular structure. As a compound with both amino and hydroxyl groups, its solubility in various solvents can be influenced by the following factors:

  • Polar Nature: The presence of the amino (-NH2) and hydroxyl (-OH) groups generally enhances the compound's solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules significantly contributes to its aqueous solubility.
  • Organic Solvents: It is expected to have variable solubility in organic solvents, with better solubility in polar solvents like ethanol or methanol compared to non-polar solvents.
  • Molecular Interactions: The steric hindrance introduced by the phenyl group may affect solubility, potentially leading to decreased solubility in highly non-polar environments.

Within the context of its practical applications, understanding the solubility of 2-amino-1-phenyl-propan-1-ol is critical for its use in pharmaceuticals and other chemical formulations. Achieving the right conditions for dissolution can optimize its efficacy and bioavailability.

Interesting facts

Interesting Facts about 2-Amino-1-phenyl-propan-1-ol

2-Amino-1-phenyl-propan-1-ol is a fascinating compound that has captured the interest of chemists and researchers alike, primarily due to its applications and structural properties. Here are some noteworthy points about this compound:

  • Pharmaceutical Relevance: This compound is often studied for its potential medicinal properties. Its structure allows it to interact with various biological targets, making it a subject of interest in drug development.
  • Synthetic Applications: In synthetic organic chemistry, 2-amino-1-phenyl-propan-1-ol serves as an important intermediate. It can be utilized in the synthesis of more complex molecules, particularly in the pharmaceutical industry.
  • Chiral Center: The presence of a chiral center in its molecular structure can lead to the formation of enantiomers, which may possess different biological activities. This is a critical feature in pharmacology as different enantiomers can have varying effects on biological systems.
  • Historical Significance: The development and study of compounds like 2-amino-1-phenyl-propan-1-ol symbolize the advancement of organic chemistry, particularly in understanding and manipulating amine functionalities in organic compounds.
  • Potential for Innovation: As researchers continue to explore the potential applications of this compound, it may inspire new innovations in various fields—from materials science to medicine.

In conclusion, 2-amino-1-phenyl-propan-1-ol stands as a testament to the versatility and importance of organic compounds in both academic research and practical applications. As chemists delve deeper into its characteristics, they uncover not only its chemical beauty but also its profound implications in modern science.

Synonyms
phenylpropanolamine
2-Amino-1-phenyl-1-propanol
48115-38-4
2-amino-1-phenylpropan-1-ol
(1S,2R)-(+)-Norephedrine
Propadrine
alpha-(1-aminoethyl)benzyl alcohol
NSC-120735
UNII-683H0R9659
2-Amino-2-methyl-1-phenylethanol
2-Amino-1-hydroxy-1-phenylpropane
beta-Hydroxy-alpha-methylphenethylamine
Benzenemethanol, alpha-(1-aminoethyl)-
Benzenemethanol, .alpha.-(1-aminoethyl)-
2-Amino-1-phenyl-propan-1-ol
Fenilpropanolamina
DTXSID70859305
683H0R9659
14838-15-4
37577-28-9
Norpseudoephedrine, (+)-
CHEMBL136560
2-Amino-1-phenyl-1-propanol #
Dexatrim
NSC-9920
Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)-rel-
Norephedrine, (+)
Norephedrine, (-)
TAVIST-D
1-phenyl-2-aminopropanol
Benzenemethanol, .alpha.-(1-aminoethyl)-, [R-(R*,S*)]-
SCHEMBL98589
Norephedrine, (.+/-.)-
CHEMBL61006
DivK1c_000795
2-amino-1-phenylpropane-1-ol
(1s, 2r)-(+)-norephedrine
(1 S,2R)-(+)-norephedrine
KBio1_000795
DTXCID00196755
NINDS_000795
(1S, 2R )-(+)-norephedrine
(+)2-Amino-1-phenyl-propan-1-ol
BDBM50022722
NSC120735
AKOS015891154
benzene, (2-amino-1-hydroxy)propyl-
IDI1_000795
58550-13-3
Pseudonorephedrine, (+) [cathine, (+)]
Pseudonorephedrine, (-) [cathine, (-)]
BENZENEMETHANOL, A-(1-AMINOETHYL)-
DB-042930
DB-069567
DB-227181
DS-010163
(1R, 2R)-2-Amino-1-phenyl-propan-1-ol
(1R, 2S)-2-Amino-1-phenyl-propan-1-ol
(1S, 2R)-2-Amino-1-phenyl-propan-1-ol
(1S, 2S)-2-Amino-1-phenyl-propan-1-ol
NS00007879
L001077
Benzenemethanol, .alpha.-(1-aminoethyl)-, (R*,S*)-(.+/-.)-
628-077-1