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Norephedrine hydrochloride

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Identification
Molecular formula
C9H13NO · HCl
CAS number
156-29-4
IUPAC name
2-amino-1-phenyl-propan-1-ol;hydrochloride
State
State

The compound is commonly found in a solid state at room temperature.

Melting point (Celsius)
133.00
Melting point (Kelvin)
406.15
Boiling point (Celsius)
223.00
Boiling point (Kelvin)
496.15
General information
Molecular weight
185.67g/mol
Molar mass
185.6700g/mol
Density
1.1000g/cm3
Appearence

Norephedrine hydrochloride typically appears as a white to off-white crystalline powder. It is odorless and is soluble in water.

Comment on solubility

Solubility of 2-amino-1-phenyl-propan-1-ol;hydrochloride

The solubility of 2-amino-1-phenyl-propan-1-ol hydrochloride is influenced by several factors, including temperature, pH, and the presence of other ions. Generally, this compound is known to be soluble in water due to its ionic nature. Here are some key points regarding its solubility:

  • Water Solubility: This compound readily dissolves in water, which is typical for many hydrochloride salts.
  • Polar Solvents: It may also exhibit solubility in other polar solvents, making it versatile in various chemical reactions.
  • Temperature Dependence: As with many soluble compounds, solubility can increase with temperature, allowing for more robust applications in both laboratory and industrial settings.
  • pH Sensitivity: Changes in pH can affect the ionization state of the compound, potentially altering solubility; hence, solutions should be buffered when necessary.

Due to its hydrochloride form, it can be stated that 2-amino-1-phenyl-propan-1-ol hydrochloride often demonstrates a good degree of solubility, making it suitable for various aqueous applications.

Interesting facts

Interesting Facts about 2-Amino-1-Phenyl-Propan-1-Ol Hydrochloride

2-Amino-1-phenyl-propan-1-ol hydrochloride is a notable compound in the field of medicinal chemistry, mainly due to its interesting structural characteristics and potential biological applications.

Key Characteristics

  • Structure and Function: The compound features an amino group that is responsible for its reactivity and interaction with biological systems. Its phenyl group enhances stability and potency.
  • Pharmacological Activity: This compound has been investigated for its potential use in treating various neurological disorders, thanks to its properties that may influence neurotransmitter systems.
  • Chirality: The presence of a chiral center at the carbon atom bearing the amino group leads to the existence of enantiomers in this compound, which can exhibit different biological activities.
  • Safety and Regulatory Aspects: As with many compounds in drug development, it is imperative to assess the safety profile and therapeutic window of 2-amino-1-phenyl-propan-1-ol hydrochloride thoroughly.

Research Insights

As a researcher, you'll find that many studies are examining the mechanisms of action and efficacy of this compound. Some noteworthy considerations include:

  • Potential impacts on mental health disorders by acting on serotonin or dopamine pathways.
  • The role of the hydrochloride salt form in enhancing solubility, thereby facilitating absorption in biological systems.
  • Endeavors to optimize synthesis for improved yield and reduced environmental impact.

In summary, 2-amino-1-phenyl-propan-1-ol hydrochloride is more than just a chemical formula—it embodies a bridge between basic chemistry and real-world applications in pharmacology. As you delve into the intricacies of this compound, remember: "Chemistry is the study of transformation;" and this compound exemplifies that in its journey from lab synthesis to potential clinical use.

Synonyms
PHENYLPROPANOLAMINE HYDROCHLORIDE
154-41-6
2-amino-1-phenylpropan-1-ol hydrochloride
dl-Norephedrine hydrochloride
dl-Phenylpropanolamine hydrochloride
Prestwick_388
Norephedrine HCl
2-amino-1-phenyl-1-propanol hydrochloride
2-amino-1-phenylpropan-1-ol;hydrochloride
2-amino-1-phenyl-propan-1-ol hydrochloride
Phenylpropanolamine chloride
SCHEMBL4011782
CHEMBL1200695
Phenyl propanolamine hydrochloride
345909-04-8
VNA90904
AKOS027320395
Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, hydrochloride, (.alpha.R)-
DB-045612
DB-048135
DB-049620
P0742
Norephedrine-gamma,gamma,gamma-d3 hydrochloride
DL-erythro-2-Amino-1-phenyl-1-propanol hydrochloride
Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, hydrochloride (1:1), (.alpha.S)-rel-