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Levothyroxine

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Identification
Molecular formula
C15H11I4NO4
CAS number
51-48-9
IUPAC name
2-amino-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]acetic acid
State
State
Levothyroxine is typically found in a solid state at room temperature, commonly in the form of tablets or capsules for medical use.
Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
211.00
Boiling point (Kelvin)
484.15
General information
Molecular weight
776.87g/mol
Molar mass
776.8700g/mol
Density
1.6800g/cm3
Appearence

Levothyroxine appears as a white to off-white crystalline powder. The compound is usually odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 2-amino-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]acetic acid

The solubility of 2-amino-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]acetic acid in various solvents can be influenced by multiple factors, primarily due to its complex molecular structure and the presence of multiple functional groups. Here are some key points to consider regarding its solubility:

  • Polarity: The introduction of multiple iodine atoms typically increases the compound's molecular mass and influences polarity. This could lead to limited solubility in non-polar solvents.
  • Hydrogen Bonding: The presence of hydroxyl (-OH) and amino (-NH2) groups suggests that the compound may engage in hydrogen bonding, enhancing solubility in polar solvents such as water.
  • Temperature Dependency: Solubility may increase with temperature. Therefore, warming polar solvents could improve the dissolution of this compound.
  • pH Variability: Since the compound contains acidic and basic sites, its solubility may vary according to the pH of the solution, highlighting the importance of the ionic state in dissolution.

In summary, while 2-amino-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]acetic acid may exhibit some degree of solubility in polar solvents such as water and alcohols, its overall solubility is likely to be limited in non-polar solvents. The exact behavior can vary significantly based on environmental factors.

Interesting facts

Interesting Facts about 2-amino-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]acetic acid

This intriguing compound, often referenced in studies related to medicinal chemistry, serves as a noteworthy example of how molecular structure can influence biological activity. Here are some fascinating points:

  • Pharmacological Relevance: This compound has been studied for its potential role in treating various diseases, particularly due to the presence of iodine atoms which can enhance biological efficacy.
  • Structural Complexity: The presence of multiple functional groups, such as amino and phenolic structures, contributes to its intricate chemical behavior. This complexity can lead to diverse interactions within biological systems.
  • Research Potential: Scientists are increasingly interested in investigating this compound for its anti-cancer properties due to its mechanism of action in disrupting cellular processes.
  • Synthetic Pathways: The synthesis of this compound involves multiple steps with various reagents, showcasing the integration of organic chemistry principles. Understanding these pathways is crucial for efficient production.
  • Environmental Impact: Iodinated compounds have been scrutinized for their environmental effects, leading to increased focus on this compound’s degradation and overall ecological safety.

In essence, 2-amino-2-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]acetic acid is not just a chemical entity but a focal point of research that bridges organic chemistry with pharmacology, offering insights into the design of new therapeutic agents. As researchers continue to unravel its properties, we may uncover even more applications that could contribute to advancements in medicine.

Synonyms
SCHEMBL8196784