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Fluorophenylalanine

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Identification
Molecular formula
C9H10FNO2
CAS number
138-85-2
IUPAC name
2-amino-3-(2-fluorophenyl)propanoic acid
State
State

At room temperature, Fluorophenylalanine is typically found in the solid state.

Melting point (Celsius)
187.00
Melting point (Kelvin)
460.15
Boiling point (Celsius)
302.00
Boiling point (Kelvin)
575.15
General information
Molecular weight
181.18g/mol
Molar mass
181.1810g/mol
Density
1.3060g/cm3
Appearence

Fluorophenylalanine is a solid compound typically appearing as a white crystalline powder. Its appearance is consistent with other amino acids and it is often used in research settings to study protein synthesis.

Comment on solubility

Solubility of 2-amino-3-(2-fluorophenyl)propanoic acid

The solubility of 2-amino-3-(2-fluorophenyl)propanoic acid, a compound containing both amino and carboxylic acid functional groups, reflects its unique structural characteristics. Due to the presence of these polar functional groups, the compound tends to exhibit moderate solubility in water. Here are some key points regarding its solubility:

  • Solvent Interaction: The amino group (-NH2) can form hydrogen bonds with water, enhancing solubility.
  • Hydrophobic Effect: The 2-fluorophenyl moiety introduces a hydrophobic character, which may slightly reduce overall solubility in aqueous media.
  • Temperature Dependence: As with many organic acids, solubility can increase with temperature, making it more soluble in warmer aqueous solutions.
  • Potential Alterations: Solubility may be affected by factors such as pH, where elevated pH levels can lead to deprotonation of the carboxylic acid, enhancing solubility.

In summary, while 2-amino-3-(2-fluorophenyl)propanoic acid demonstrates appreciable solubility in water due to its polar functional groups, its hydrophobic regions still pose some challenges. Understanding these solubility characteristics is crucial for applications in pharmaceutical and chemical sciences.

Interesting facts

Interesting Facts about 2-amino-3-(2-fluorophenyl)propanoic Acid

2-amino-3-(2-fluorophenyl)propanoic acid, often referred to in scientific contexts by its systematic name or shorthand, is a fascinating compound with significant implications in the field of organic chemistry and pharmacology. Below are some intriguing insights:

  • Biological Relevance: This compound is a derivative of amino acids, making it an important building block in biochemistry. Amino acids are the *foundation of proteins*, which perform a myriad of functions within biological organisms.
  • Fluorine's Impact: The presence of a fluorine atom in the phenyl group introduces unique properties. Fluorinated compounds can exhibit altered reactivity and pharmacokinetics, which can be beneficial in drug design by enhancing *bioavailability* and *selectivity*.
  • Research Applications: Compounds like this one are often explored in medicinal chemistry as potential therapeutic agents. They can be investigated for their role in modulating neurotransmitter receptors, providing insights into neurological and psychiatric disorders.
  • Synthesis Techniques: The synthesis of 2-amino-3-(2-fluorophenyl)propanoic acid can involve various organic reactions, including nucleophilic substitution and amine coupling reactions. Understanding these pathways is crucial for developing efficient manufacturing processes in pharmaceuticals.
  • Stereochemistry: As a chiral molecule, it exists in multiple stereoisomeric forms that can exhibit different biological activities. The study of its stereochemistry is important for evaluating its efficacy and safety profiles in drug development.
  • Potential Side Effects: As with many compounds interacting with biological systems, research into this compound must also consider potential side effects, which can arise from its interaction with various receptors or biological pathways.

In summary, 2-amino-3-(2-fluorophenyl)propanoic acid is more than just a chemical entity; it represents a convergence of chemical science and biological significance that is crucial in the ongoing quest for new therapeutic agents. As chemists continue to explore its properties and applications, this compound illustrates the profound connection between *chemical structure* and *biological function*.

Synonyms
2-Fluoro-dl-phenylalanine
2629-55-2
2-amino-3-(2-fluorophenyl)propanoic acid
2-Fluorophenylalanine
o-Fluorophenylalanine
325-69-9
o-Fluoro-dl-phenylalanine
3-(o-Fluorophenyl)alanine
Phenylalanine, 2-fluoro-
dl-(2-Fluorophenyl)alanine
MFCD00004271
2-fluoro-Phe
ortho-fluorophenylalanine
35175-89-4
ALANINE, 3-(o-FLUOROPHENYL)-
DL-2-FLUOROPHENYLALANINE
CHEBI:155833
3-(2-fluorophenyl)-2-aminopropionic acid
DTXSID90924286
DL-Phenylalanine, 2-fluoro-
DL-3-(2-Fluorophenyl)alanine
oFluorophenylalanine
DL-o-phenylalanine
EINECS 220-105-7
Phenylalanine, 2fluoro
3(oFluorophenyl)alanine
dl-o-Fluorophenylalanine
2-Fluorophenylalanine #
2-Amino-3-(2-fluorophenyl)propionic Acid
2-Amino-3-(2-fluoro-phenyl)-propionic acid
Alanine, 3(ofluorophenyl)
TimTec1_001819
SCHEMBL44126
H-DL-PHE(2-F)-OH
Phenylalanine, 2fluoro (9CI)
dl-.beta.-o-Fluorophenylalanine
CHEMBL4597435
Phenylalanine, 2-fluoro-(9CI)
DTXCID401353129
DTXSID501313097
HMS1539C15
ALBB-014711
o-Fluoro-DL-phenylalanine, >=98%
STL374077
AKOS000184152
AKOS016344084
AB00346
AB02696
AB02697
CS-W017053
HY-W016337
2-amino-3-(2-fluorophenyl)propanoicacid
AS-64482
PD196712
SY040068
SY049820
SY106935
DB-021131
DB-045019
DB-046920
F0170
BRD-A54914915-001-01-6
(S)-2-AMINO-3-(2'-FLUOROPHENYL)PROPANOIC ACID
F2147-6664